非小细胞肺癌Ki-ras基因第12位密码子突变与吸烟的关系

被引：1

作者：

胡毅玲

吴一龙

云径平

池桂波

王声湧

机构：

[1] 暨南大学医学院流行病学教研室

[2] 中山医科大学附属肿瘤医院

来源：

疾病控制杂志 | 1999年 / 02期

关键词：

肺癌；Ki－ras基因；吸烟;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100214 ;

摘要：

目的探讨Ｋｉ－ｒａｓ基因突变在肺癌不同病理型中的分布及与吸烟的关系。方法采用聚合酶链反应－单链构象多态性分析（ＰＣＲ－ＳＳＣＰ）检测４０例肺癌病理标本Ｋｉ－ｒａｓ基因第１２位密码子点突变。结果检出６例突变者，突变率为１５％。腺癌和鳞癌的突变率分别为１７．４％（４／２３）和１３．３％（２／１５），无显著性差异（χ２＝１．４３，Ｐ＞０．０５）。有吸烟史的肺癌突变率为６．４５％（２／３１），非吸烟肺癌中突变率为４４．４％（４／９）。结论在非小细胞肺癌中未发现Ｋｉ－ｒａｓ基因突变与吸烟有关。

引用

页码：16 / 17

页数：2

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