促炎细胞因子对肠上皮细胞紧密连接调控的分子机制

被引：10

作者：

顾立立

李宁

机构：

[1] 第二军医大学南京临床医学院(南京军区南京总医院)解放军普通外科研究所

来源：

肠外与肠内营养 | 2008年 / 02期

关键词：

促炎细胞因子; 肠上皮; 紧密连接; 分子机制;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

促炎细胞因子是由细胞分泌的、具有促进和调节炎性反应作用的小分子多肽,主要有IL-1、IL-6、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)等。炎症性肠病病人血清中促炎细胞因子水平显著增高,并且能引起肠上皮细胞紧密连接的改变。现就促炎细胞因子对肠上皮细胞紧密连接调控的分子机制作一综述,旨在为开展基础研究和临床提供参考。

引用

收藏

页码：114 / 118

页数：5

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