糖尿病肾病内皮细胞损伤机制的研究进展

被引：30

作者：

陈碧霞

张利

吴玲玲

陈香美

机构：

[1] 广东药科大学临床医学院/国家肾脏病临床医学研究中心

来源：

解放军医学杂志 | 2020年 / 08期

关键词：

糖尿病肾病; 内皮细胞损伤; 细胞间通讯; 表观遗传学;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R692.9 [其他疾病];

学科分类号：

1002 ; 100201 ; 100210 ;

摘要：

糖尿病肾病是糖尿病微小血管并发症之一,其主要表现为进行性的蛋白尿和肾功能衰退,最终发展为终末期肾病。肾小球内皮细胞是肾小球滤过屏障的重要组成部分,其结构及功能的完整性与肾小球滤过功能关系密切。肾小球内皮细胞功能障碍对糖尿病肾病的发生、发展起着重要作用,导致内皮功能障碍的经典机制除糖代谢紊乱、氧化应激、异常血管新生、炎症及内皮转分化等,还包括细胞间通讯、表观遗传学及外泌体等新机制。该文就肾小球内皮细胞在糖尿病肾病中损伤的相关机制研究进展进行了综述。

引用

页码：876 / 883

页数：8

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