关于中药质量控制与体内代谢研究的思考

被引:10
作者
叶敏
果德安
机构
[1] 北京大学药学院
关键词
中药; 质量控制; 体内代谢; 指纹图谱;
D O I
暂无
中图分类号
R28 [中药学];
学科分类号
1008 ;
摘要
质量控制是保证中药安全、有效的重要基础。体内代谢研究可以为阐明中药的治病机制提供依据。本文以蟾酥为例,讨论了当前中药质量控制及体内代谢研究存在的主要问题和解决办法:认为把中药指纹图谱的全面指认与多指标成分定量相结合是有效控制中药质量的可行途径;液相色谱-质谱联用技术(LC/MS)将在中药化学研究、体内代谢研究等方面发挥重要作用;中药的化学指纹图谱应与药理活性相关联,从而建立合理的中药质量评价体系;结构修饰对基于天然产物的新药发现具有重要意义。
引用
收藏
页码:100 / 104
页数:5
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