蛛网膜下腔出血后脑血管痉挛的研究进展

被引：8

作者：

段鸿洲

莫大鹏

机构：

[1] 北京大学第一医院神经外科

来源：

医学综述 | 2009年 / 15卷 / 15期

基金：

高等学校博士学科点专项科研基金;

关键词：

蛛网膜下腔出血; 脑血管痉挛; 炎性因子; 诊断; 治疗;

D O I：

暂无

中图分类号：

R743.35 [蛛网膜下腔出血];

学科分类号：

1002 ;

摘要：

脑血管痉挛是蛛网膜下腔出血后常见而危险的并发症,其导致的继发性缺血性脑损害是致死致残的主要原因。目前关于蛛网膜下腔出血引起脑血管痉挛的发病机制、诊断及治疗均为研究热点,且也是临床亟待解决的问题。但关于其确切的发病机制、诊断及治疗方法均未统一,尚存在较大争议。关于其发病机制学说,主要包括气体信号分子学说和炎性反应学说;目前对其诊断主要依赖脑血管造影、CT灌注成像、经颅多普勒超声等检查方法;针对其治疗,可采用药物治疗、脑脊液引流、血管内介入治疗或基因治疗等方法。本文就近期关于蛛网膜下腔出血后脑血管痉挛的形成机制、诊断及治疗的进展进行综述。

引用

页码：2287 / 2291

页数：5

共 13 条

[1] ANGIOGRAPHIC AND HEMODYNAMIC EFFECT OF HIGH CONCENTRATION OF INTRA-ARTERIAL NICARDIPINE IN CEREBRAL VASOSPASM [J].

Linfante, Italo ;

Delgado-Mederos, Raquel ;

Andreone, Vincenzo ;

Gounis, Matthew ;

Hendricks, Laura ;

Wakhloo, Ajay K. .

NEUROSURGERY, 2008, 63 (06) :1080-1086

[2] Dopamine D2-Receptor-Mediated Increase in Vascular and Endothelial NOS Activity Ameliorates Cerebral Vasospasm After Subarachnoid Hemorrhage In Vitro [J].

Pyne-Geithman, Gail J. ;

Caudell, Danielle N. ;

Cooper, Matthew ;

Clark, Joseph F. ;

Shutter, Lori A. .

NEUROCRITICAL CARE, 2009, 10 (02) :225-231

[3]

Effect of Prophylactic Transluminal Balloon Angioplasty on Cerebral Vasospasm and Outcome in Patients With Fisher Grade III Subarachnoid Hemorrhage: Results of a Phase II Multicenter, Randomized, Clinical Trial[J] . Marike Zwienenberg-Lee,Jonathan Hartman,Nancy Rudisill,Lori Kennedy Madden,Karen Smith,Joseph Eskridge,David Newell,Bon Verweij,M Ross Bullock,Andrew Baker,William Coplin,Robert Mericle,Jian Dai,David Rocke,J Paul Muizelaar.Stroke . 2008 (6)

[4]

Soybean-based biomaterials: preparation, properties and tissue regeneration potential[J] . Santin,Ambrosio.Expert Review of Medical Devices . 2008 (3)

[5]

GUIDELINES FOR THE SURGICAL TREATMENT OF UNRUPTURED INTRACRANIAL ANEURYSMS: THE FIRST ANNUAL J. LAWRENCE POOL MEMORIAL RESEARCH SYMPOSIUM—CONTROVERSIES IN THE MANAGEMENT OF CEREBRAL ANEURYSMS[J] . Ricardo J. Komotar,J Mocco,Robert A. Solomon.Neurosurgery . 2008 (1)

[6] Expression and function of inwardly rectifying potassium channels after experimental subarachnoid hemorrhage [J].

Weyer, GW ;

Jahromi, BS ;

Aihara, Y ;

Agbaje-Williams, M ;

Nikitina, E ;

Zhang, ZD ;

Macdonald, RL .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (03) :382-391

[7] Nitric oxide in subarachnoid haemorrhage and its therapeutics implications [J].

Haenggi, D. ;

Steiger, H. -J. .

ACTA NEUROCHIRURGICA, 2006, 148 (06) :605-613

[8] Management of cerebral vasospasm [J].

Macdonald, R. Loch .

NEUROSURGICAL REVIEW, 2006, 29 (03) :179-193

[9]

Computed Tomographic Perfusion in the Management of Aneurysmal Subarachnoid Hemorrhage: New Application of an Existent Technique[J] . Mark R. Harrigan,Christopher R. Magnano,Lee R. Guterman,L Nelson Hopkins.Neurosurgery . 2005 (2)

[10] Expression of interleukin-1β in lipopolysaccharide stimulated monocytes derived from patients with aneurysmal subarachnoid hemorrhage is correlated with cerebral vasospasm [J].

Nam, DH ;

Kim, JS ;

Hong, SC ;

Lee, WH ;

Lee, JI ;

Shin, HJ ;

Park, K ;

Eoh, W ;

Han, DH ;

Kim, JH .

NEUROSCIENCE LETTERS, 2001, 312 (01) :41-44

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