microRNA与血脂代谢

被引:4
作者
邢钰
赵水平
机构
[1] 中南大学湘雅二医院心内科
关键词
microRNA; 血脂代谢;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100103 [病原生物学];
摘要
目的 microRNA是一类内源性、高保守、大小约22个核苷酸的单链非编码RNA。microRNA广泛分布于真核细胞内,它能够通过与对应的靶mRNA3,末端非翻译区(3,UTR)特异性结合来直接降解靶mRNA或破坏其稳定性,从而抑制靶mRNA的翻译,对基因进行转录后水平的调控。microRNA调控着人类基因组中20%30%的基因,参与生物体的生长发育及多种生理病理学过程,包括细胞分化、细胞增殖、细胞凋亡,以及糖尿病、肿瘤形成、心血管疾病、神经功能紊乱、病毒感染等等。本文主要针对参与血脂代谢的microRNA作一综述。
引用
收藏
页码:586 / 588
页数:3
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