单纯性肥胖患者血清脂联素、血清瘦素与肾损伤的相关性分析附视频

被引：20

作者：

赵菊兰

夏天

李荣

李艳伟

机构：

[1] 天津医科大学第二医院肾内科

来源：

天津医科大学学报 | 2016年 / 01期

关键词：

肥胖; 脂联素; 瘦素; 尿白蛋白; 肾小球滤过率; 体质量指数; 瘦素/脂联素;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

100201 [内科学];

摘要：

目的:研究单纯性肥胖患者血清脂联素、血清瘦素与尿白蛋白、肾小球滤过率相关性及两种脂肪因子对肾脏的作用。方法:选取单纯肥胖患者(肥胖组)60例,同期健康人(对照组)40例,测定两组人群血清脂联素、血清瘦素、身高、体质量、肾功能及尿白蛋白等,计算两组人群瘦素与脂联素比值、体质量指数(BMI)及肾小球滤过率(GFR)。结果:肥胖组血清脂联素明显低于对照组(P<0.001);肥胖组血清瘦素明显高于对照组(P<0.001);肥胖组较对照组尿白蛋白差异明显(P=0.004);肥胖组血清瘦素/脂联素与对照组差异明显(P<0.001);脂联素与BMI、尿白蛋白为负相关(r分别为:-0.421、-0.245;P分别为<0.001、0.029);血清瘦素与BMI正相关(r=0.650,P<0.001),与GFR负相关(r=-0.227,P=0.043);瘦素/脂联素与BMI正相关(r=0.511,P<0.001);GFR与BMI正相关(r=0.376,P=0.001);瘦素、瘦素/脂联素、BMI与尿白蛋白无相关性;脂联素、瘦素/脂联素与GFR无相关性。结论:单纯性肥胖患者血清脂联素水平下降,血清瘦素、尿白蛋白水平升高。瘦素/脂联素比值可能是单纯性肥胖患者肾损伤预后的预测因子。

引用

页码：34 / 36+40 +40

页数：4

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