模拟失重后大鼠血压信号的递归定量分析

被引：1

作者：

刘欣 ^{[1
]}

程九华 ^{[2
]}

卢虹冰 ^{[1
]}

张立藩 ^{[2
]}

马进 ^{[2
]}

董秀珍 ^{[1
]}

机构：

[1] 第四军医大学生物医学工程系计算机应用教研室

[2] 第四军医大学航空航天生理学教研室

来源：

航天医学与医学工程 | 2006年 / 06期

关键词：

血压变异性; 非线性分析; 递归图示法; 递归定量分析法;

D O I：

10.16289/j.cnki.1002-0837.2006.06.002

中图分类号：

R85 [航空航天医学];

学科分类号：

1001 ; 100106 ;

摘要：

目的应用递归图示法和递归定量法分析清醒大鼠的血压信号,评价可否检测出模拟失重所引起的心血管调节改变。方法以尾部悬吊大鼠模型模拟失重对心血管调节功能的影响,另设同步对照动物进行比较。14d后,通过慢性植入的PE-50-PE-10聚乙烯导管连续记录清醒状态下两组大鼠的血压数据。数据处理使用递归图示法(recurrence plot analysis,RPA)对大鼠收缩压变异性(systolic bloodpressure variability,SBPV)信号的非线性特征进行定性分析;随后使用递归定量分析(recurrencequantification analysis,RQA)计算递归百分数(%REC)、确定线段百分数(%DET)和Lmax指数3个特征指标值,对其进行量化处理。结果与对照组相比,悬吊组大鼠血压的3个非线性指数均显著降低(P<0.05或0.01),表明血压波动趋于更加混沌的状态。对照组的%REC、%DET与Lmax指数分别为90.28±1.21、99.24±0.16与84.57±2.28,而模拟失重组则为74.89±2.13、93.61±2.82与57.71±2.14。结论RPA与RQA是动脉血压信号处理的一种新的方法,可以检测出14d模拟失重所引起的清醒大鼠心血管调节变化,在心血管信号分析领域中有一定应用前景。

引用

页码：394 / 398

页数：5

共 13 条

[1]

Recent advances in multi-variate and multi-dimensional analysis of heart rate variability and blood pressure variability. ZHANG Lifan,,WANG Shouyan,NIU Youguo. Space Medicine&Medical Engineering . 2002

[2]

Chaos in blood pres-sure control. Wagner CD,Nafz B,Persson PB. Cardiovascular Research . 1996

[3]

Use of nonlinear methods to assess effects of clonidine on blood pres-sure in spontaneously hypertensive rats. Mestivier D,Dabire H,Safar M,et al. Journal of Applied Physiology . 1998

[4]

Daily4-h head-up tilt is effective in preventing muscle but not bone atrophy due to simulated microgravity. SUN Biao,,CAO Xinsheng,ZHANG Lifan,et al. Journal of Gravitational Physiology . 2003

[5]

Dynamical assessment of physi-ological systems and states using recurrence plot strate-gies. Webber CL,,Zbilut JP. Journal of Applied Physiology . 1994

[6]

Mecha-nisms of the cardiovascular deconditioning induced by tail suspension in the rat. Martel E,,Ponchon P,Champeroux P,et al. American Journal of Physiology . 1998

[7]

Quantification of sympathetic and parasympathetic tones by nonlinear in-dexes in normotensive rats. Dabire H,,Mestivier D,Jarnet J,et al. American Journal of Physiology . 1998

[8]

Changes of renal sympathetic activity in acute and chronic conscious sino-aortic denervated rats. Irigoyen MC,,MoreiraED,IdaF,et al. Journal of Hypertension . 1995

[9]

Cardiovascular varia-bility and baroreceptor reflex sensitivity over a14-day tail suspension in rats. Fagette S,,Lo M,Gharib C,et al. Journal of Applied Physiology . 1995

[10]

Heart rate and blood pressure variability:analytical methods,physiological significance and its ap-plications. ZHANG Lifan. Progress in Physics . 1996

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