肿瘤相关巨噬细胞参与肿瘤免疫调节的研究进展

被引：6

作者：

廉祎

黄瑛

机构：

[1] 中国医科大学附属盛京医院超声科

来源：

解剖科学进展 | 2018年 / 24卷 / 05期

关键词：

肿瘤免疫; 免疫抑制; TAM; PD; 肿瘤微环境; 细胞因子; 肿瘤相关巨噬细胞; 肿瘤细胞;

D O I：

10.16695/j.cnki.1006-2947.2018.05.025

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

100214 ;

摘要：

肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)是肿瘤微环境(tumor microenvironment,TME)中一种重要的炎症细胞,依据功能表型不同,大致分为M1型和M2型。TAMs分泌多种细胞因子,趋化因子和蛋白酶等,促进细胞外基质重塑,肿瘤细胞生长、转移,肿瘤血管、淋巴管新生及免疫抑制。TAMs的主要致病活性是免疫抑制反应,其在肿瘤的进展中起重要的作用,目前肿瘤免疫学进展也揭示了免疫抑制细胞TAMs的重要性,本文主要综述TAMs参与免疫抑制的机制及相关的细胞因子,及靶向这些因子免疫治疗的研究进展。

引用

页码：542 / 546

页数：5

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