原发性胆汁性肝硬化外周血T细胞亚群及细胞因子的检测

被引：10

作者：

何文革

孙永涛

邹爱民

机构：

[1] 第四军医大学唐都医院全军感染病诊疗中心

[2] 唐都医院中心实验室西安

[3] 西安

来源：

胃肠病学和肝病学杂志 | 2004年 / 05期

关键词：

原发性胆汁性肝硬化; T细胞亚群; 细胞因子;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

1002 ; 100201 ;

摘要：

目的　探讨中国人原发性胆汁性肝硬化患者的T细胞亚群及细胞因子存在状况及意义。方法　选未经特殊治疗的原发性胆汁性肝硬化（PBC） 2 5例 ,性别、年龄匹配的健康人 2 0例作为对照组。以双抗体夹心ELISA法检测外周血细胞因子IL2、IFNγ、IL4、IL10、TNFα水平。以SP法检测外周血T淋巴细胞亚群。结果　与对照组比较 ,PBC患者CD+ 4 T细胞升高 ,CD+ 8T细胞下降 ,CD+ 4 /CD+ 8比值上升（P <0 0 1）。PBC组IL2、IFNγ、TNFα明显升高（P <0 0 1） ,IL10轻度上升（P <0 0 5 ） ,IL4水平与对照组比较无差异（P >0 0 5 ）。结论　PBC外周血CD+ 4 T细胞和Th1细胞因子占优势 ,提示其在PBC发病机制中发挥重要作

引用

页码：511 / 513

页数：3

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