凋亡诱导基因TRAIL的受体在卵巢肿瘤中的表达

被引：8

作者：

李新国

张瑜

谌兵来

机构：

来源：

湖南医科大学学报 | 2000年 / 05期

关键词：

卵巢肿瘤; 凋亡; TRAIL; 基因受体;

D O I：

暂无

中图分类号：

R737.31 [卵巢肿瘤];

学科分类号：

100214 ;

摘要：

应用RT PCR方法检测 3例正常卵巢、6例良性卵巢肿瘤和 16例恶性卵巢肿瘤组织中TNF家族新成员TRAIL的受体DR5 ,DcR1和DcR2表达。结果显示 :正常人外周血淋巴细胞及 3例正常卵巢组织中TRAIL受体均为阳性表达。良性卵巢肿瘤中DR5阳性表达率为 83.3% (5 /6 ) ,DcR1为 83.3% (5 /6 ) ,DcR2为 10 0 % (6 /6 )。恶性卵巢肿瘤中DR5阳性表达率为 6 8.8% (11/16 ) ,DcR1为 6 8.8% (11/16 ) ,DcR2为 0 % (0 /16 )。提示不同TRAIL受体特别是DcR2表达可能参与了卵巢肿瘤发生过程中细胞凋亡的调控

引用

页码：471 / 473

页数：3

共 11 条

[1]

Expression of TRAIL and its receptor in human brain tumors. Frank S,Kler U,Schackert G,et al. Biochemical and Biophysical Research Communications . 1999

[2]

Rare loss-of function mutation of a death receptor gene in head and neck cancer. Pai SI. Cancer Research . 1998

[3]

Iddentification and characterization of a new member of the TNF family that induces apoptosis. Wiley SR,Schooey K,Smolak PJ,et al. Immunity . 1995

[4]

The p53 tumour suppressor gene frequently is altered in gynecologic cancer. Berchuck A,Kohler MF,Marks JR,et al. American Journal of Obstetrics and Gynecology . 1994

[5]

The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis yet retains an incomplete death domain. Degli-Esposti MA,Dougall WC,Smolak PJ,et al. Immunity . 1997

[6]

TRAIL: a molecule with multiple receptors and control mechanisms. Griffith TS,Lynch DH. Current Opinion in Immunology . 1998

[7]

An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Pan G,Ni J,Wei Y-F,et al. Science . 1997

[8]

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Wu GS,Burns TF,McDonald ER 3rd,et al. Nature Genetics . 1997

[9]

Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. Griffith TS,Chin WA. J Immunol . 1998

[10]

Cloning and characterization of TRAIL R3, a novel member of the emerging TRAIL receptor family. Degli-Esposti MA,Smolak PJ,Walczak H. et al. The Journal of Experimental Medicine . 1997

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