肿瘤个体化治疗的现状和前景

被引:11
作者
韩晓红 [1 ]
马丽 [2 ]
石远凯 [2 ]
机构
[1] 北京协和医学院中国医学科学院肿瘤医院肿瘤研究所内科检验科
[2] 北京协和医学院中国医学科学院肿瘤医院肿瘤研究所内科
关键词
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 [肿瘤学];
摘要
<正>20世纪70年代以来,人类基因组研究成果斐然,肿瘤基因组学、RNA组学和蛋白质组学等基础研究向临床实践拓展,使传统经验治疗模式逐渐向依据生物标志物的个体化治疗模式转变。越来越多的临床研究证实,通过检测肿瘤患者生物标本中生物标志物的基因突变、基因SNP分型、mRNA基因
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共 12 条
[1]
应用FISH和IHC技术检测中国乳腺癌患者HER-2基因状态及蛋白表达的前瞻性多中心研究题录附视频 [J].
韩晓红 ;
石远凯 ;
马丽 ;
吕铮 ;
杨红鹰 ;
姚嘉瑞 ;
李坚 ;
李博 ;
秦燕 .
中华检验医学杂志, 2010, (07)
[2]
UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer [J].
Schulz, Christoph ;
Heinemann, Volker ;
Schalhorn, Andreas ;
Moosmann, Nikolas ;
Zwingers, Thomas ;
Boeck, Stefan ;
Giessen, Clemens ;
Stemmler, Hans-Joachim .
WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (40) :5058-5066
[3]
恶性肿瘤个体化治疗靶向药物的临床表现.[J]..中华肿瘤杂志.2010, 10
[4]
Clinical Significance of the 21-Gene Signature (Oncotype DX) in Hormone Receptor-Positive Early Stage Primary Breast Cancer in the Japanese Population [J].
Toi, Masakazu ;
Iwata, Hiroji ;
Yamanaka, Takeharu ;
Masuda, Norikazu ;
Ohno, Shinji ;
Nakamura, Seigo ;
Nakayama, Takahiro ;
Kashiwaba, Masahiro ;
Kamigaki, Shunji ;
Kuroi, Katsumasa .
CANCER, 2010, 116 (13) :3112-3118
[5]
Evaluation of HER2/neu oncoprotein in serum and tissue samples of women with breast cancer: Correlation with clinicopathological parameters [J].
Farzadnia, Mehdi ;
Meibodi, Naser Tayyebi ;
Shandiz, Fatemeh Homayi ;
Mahmoudi, Mahmoud ;
Bahar, Mostafa Mehrabi ;
Memar, Bahram ;
Amoian, Sakineh ;
Maroozi, Farshad ;
Moheghi, Nasrin .
BREAST, 2010, 19 (06) :489-492
[6]
Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer [J].
He, Qiong ;
Chen, Hua-Yun ;
Bai, En-Qi ;
Luo, Yan-Xin ;
Fu, Rui-Jia ;
He, Yun-Shao ;
Jiang, Jie ;
Wang, Hua-Qiao .
CANCER GENETICS AND CYTOGENETICS, 2010, 202 (01) :1-10
[7]
Topoisomerase IIα expression rather than gene amplification predicts responsiveness of adjuvant anthracycline-based chemotherapy in women with primary breast cancer [J].
Schindlbeck, Christian ;
Mayr, D. ;
Olivier, C. ;
Rack, B. ;
Engelstaedter, V. ;
Jueckstock, J. ;
Jenderek, C. ;
Andergassen, U. ;
Jeschke, U. ;
Friese, K. .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2010, 136 (07) :1029-1037
[8]
Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751,871) in Combination with Paclitaxel and Carboplatin [J].
Karp, Daniel D. ;
Pollak, Michael N. ;
Cohen, Roger B. ;
Eisenberg, Peter D. ;
Haluska, Paul ;
Yin, Donghua ;
Lipton, Allan ;
Demers, Laurence ;
Leitzel, Kim ;
Hixon, Mary L. ;
Terstappen, Leon W. ;
Garland, Linda ;
Paz-Ares, Luis G. ;
Cardenal, Felipe ;
Langer, Corey J. ;
Gualberto, Antonio .
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (11) :1397-1403
[9]
The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer [J].
Straver, Marieke E. ;
Glas, Annuska M. ;
Hannemann, Juliane ;
Wesseling, Jelle ;
van de Vijver, Marc J. ;
Rutgers, Emiel J. Th. ;
Peeters, Marie-Jeanne T. F. D. Vrancken ;
van Tinteren, Harm ;
van't Veer, Laura J. ;
Rodenhuis, Sjoerd .
BREAST CANCER RESEARCH AND TREATMENT, 2010, 119 (03) :551-558
[10]
Is class III β-tubulin a predictive factor in patients receiving tubulin-binding agents? [J].
Seve, Pascal ;
Dumontet, Charles .
LANCET ONCOLOGY, 2008, 9 (02) :168-175