PPs在免疫相关肠病中的病理机制及中药多糖的调控作用

被引：11

作者：

蒲秀兰 ^{[1
]}

林美斯 ^{[1
,2
]}

罗锐锋 ^{[1
]}

陈其艳 ^{[1
]}

董玲玲 ^{[1
]}

林大胜 ^{[1
,3
]}

高飞 ^{[1
]}

机构：

[1] 成都中医药大学药学院省部共建西南特色中药资源国家重点实验室

[2] 四川省针灸学校

[3] 成都华神科技集团股份有限公司

来源：

中国实验方剂学杂志 | 2021年 / 27卷 / 04期

关键词：

中药多糖; 肠道派氏结; 溃疡性结肠炎; 作用机制;

D O I：

暂无

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

肠道派氏结(PPs)是肠的局部免疫组织,被认为是肠道黏膜免疫反应的主要诱导部位,与免疫性相关肠病,如溃疡性结肠炎、肠道黏膜损伤等关系密切。近年来越来越多的学者想通过深入研究PPs与肠病的相关性,为临床干预作用非常有限的难治性肠病寻找新的突破口。中药多糖被认为是中药免疫调节的关键成分,现代研究显示中药多糖对PPs的结构和功能具有积极的明显的干预作用,展现出良好的开发前景。据此,本论文聚焦PPs与免疫相关肠病,通过系统介绍PPs的生理结构及其递药机制,梳理PPs与免疫相关肠病作用关系研究进展,分析中药多糖通过调节PPs干预免疫相关肠病及其功能失调现状和前景,旨在通过PPs角度,为免疫相关肠病基础研究和临床治疗提供新策略,为中药多糖干预肠病的基础研究和临床研究提供新思路。

引用

页码：216 / 224

页数：9

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