西红花苷和西红花酸在小鼠体内抗氧化活性对比研究

被引：44

作者：

陈阳 ^{[1
]}

杨婷 ^{[2
]}

黄娟 ^{[2
]}

田西 ^{[2
]}

赵璨 ^{[2
]}

蔡乐 ^{[2
]}

冯丽娟 ^{[1
]}

张浩 ^{[2
]}

机构：

[1] 遵义医学院珠海校区化学教研室

[2] 四川大学华西药学院生药学教研室

来源：

中国药理学通报 | 2010年 / 02期

关键词：

栀子; 西红花酸; 西红花苷; 体内; 抗氧化; 对比;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的对比评价西红花苷和西红花酸在小鼠体内抗氧化活性。方法采用硅胶柱层析从栀子中分离西红花酸和西红花苷纯品,普通昆明小鼠灌胃给药西红花酸和西红花苷,剂量分别是西红花酸6.25、12.5和25.0mg·kg-1和西红花苷18.7、37.5和75.0mg·kg-1.d-1,采用测定普通小鼠体内抗氧化指标(SOD、GSH-Px、TAOC和MDA)的方法对比评价西红花酸和西红花苷-1体内抗氧化活性。结果两种化合物都能明显提高小鼠肾脏和肝脏的SOD,肝脏的GSH-Px,心脏和肾脏的TAOC,降低血浆的MDA。结论西红花酸和西红花苷-1具有相似的体内抗氧化活性,其主要活性部位可能是肝脏和肾脏。

引用

页码：248 / 251

页数：4

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