Toll样受体通过炎性反应和免疫反应介导心肌纤维化的研究进展

被引：4

作者：

吴限

黎明江

机构：

[1] 武汉大学人民医院心内科/武汉大学心血管病研究所/心血管病湖北省重点实验室

来源：

疑难病杂志 | 2017年 / 05期

关键词：

Toll样受体; 心肌纤维化; 炎性反应; 免疫反应;

D O I：

暂无

中图分类号：

R542.23 [];

学科分类号：

摘要：

Toll样受体(TLRs)是一类介导固有免疫反应,具有Ⅰ型跨膜蛋白并能识别大量外源性配体的重要受体。TLRs不仅能够抵抗病原微生物的入侵,而且在心肌缺血再灌注性损伤、动脉粥样硬化、高血压等非感染性损伤介导的心肌纤维化过程中发挥着十分重要的作用。文章从免疫反应及炎性反应角度出发,就国内外有关TLRs尤其是TLR4在心肌纤维化中可能作用机制研究进展做一综述,希望能进一步阐明心肌纤维化潜在的发生机制,同时也期许为心肌纤维化的防治提供新的视角。

引用

页码：525 / 529

页数：5

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