高同型半胱氨酸血症与冠状动脉粥样硬化性心脏病关系的研究进展

被引:33
作者
胡云辉 [1 ]
马依彤 [2 ]
机构
[1] 新疆医科大学
[2] 新疆医科大学第一附属医院心脏中心
关键词
高同型半胱氨酸血症; 冠心病; 同型半胱氨酸;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
高同型半胱氨酸血症作为冠心病的独立危险因素已受到重视。其通过导致血管内皮损伤、促进炎性因子的释放、刺激血管平滑肌细胞增生及钙化、影响脂质代谢、促进动脉血栓形成等途径引起动脉粥样硬化。大量的研究还证实高同型半胱氨酸血症是冠心病的独立预测因子,不仅可用于判断冠心病及其严重程度,还可用于判断急性冠脉综合征和介入治疗的预后。
引用
收藏
页码:682 / 685
页数:4
相关论文
共 11 条
  • [1] The use of an in vivo model to study the effects of hyperhomocysteinaemia on vascular function
    Hansrani, Monica
    Stansby, Gerard
    Cantab, M. A.
    Chir, M.
    [J]. JOURNAL OF SURGICAL RESEARCH, 2008, 145 (01) : 13 - 18
  • [2] Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease
    Yilmaz, Hale
    Sahin, Sinan
    Sayar, Nurten
    Tangurek, Burak
    Yilmaz, Mehmet
    Nurkalem, Zekeriya
    Onturk, Ebru
    Cakmak, Nazmiye
    Bolca, Osman
    [J]. ACTA CARDIOLOGICA, 2007, 62 (06) : 579 - 585
  • [3] Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease[J] . Mohammad A. Alam,Syed A. Husain,Rajiv Narang,Shayam S. Chauhan,Madhulika Kabra,Suman Vasisht.Molecular and Cellular Biochemistry . 2008 (1)
  • [4] Homocysteine stimulates nuclear factor κB activity and interleukin-6 expression in rat vascular smooth muscle cells
    Zhang, Li
    Jin, Min
    Hu, Xiao-Sheng
    Zhu, Jian-Hua
    [J]. CELL BIOLOGY INTERNATIONAL, 2006, 30 (07) : 592 - 597
  • [5] Rosiglitazone reduces serum homocysteine levels, smooth muscle proliferation, and intimal hyperplasia in Sprague-Dawley rats fed a high methionine diet[J] . Subramanyam N. Murthy,Demian F. Obregon,Natasha N. Chattergoon,Neil A. Fonseca,Debasis Mondal,Jeffrey B. Dunne,Jose G. Diez,James R. Jeter,Philip J. Kadowitz,Krishna C. Agrawal,Dennis B. McNamara,Vivian A. Fonseca.Metabolism . 2005 (5)
  • [6] Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels
    Riba, R
    Nicolaou, AA
    Troxler, M
    Homer-Vaniasinkam, S
    Naseem, KM
    [J]. ATHEROSCLEROSIS, 2004, 175 (01) : 69 - 75
  • [7] Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells
    Li, JX
    Chai, SB
    Tang, CS
    Du, JB
    [J]. LIFE SCIENCES, 2003, 74 (04) : 451 - 461
  • [8] ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation[J] . A Jimbo,E Fujita,Y Kouroku,J Ohnishi,N Inohara,K Kuida,K Sakamaki,S Yonehara,T Momoi.Experimental Cell Research . 2003 (2)
  • [9] Plasma homocysteine levels and late outcome after coronary angioplasty
    Schnyder, G
    Flammer, Y
    Roffi, M
    Pin, R
    Hess, OM
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (10) : 1769 - 1776
  • [10] Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease[J] . Frank F Willems,Wim R.M Aengevaeren,Godfried H.J Boers,Henk J Blom,Freek W.A Verheugt.Journal of the American College of Cardiology . 2002 (4)