Wnt/β-catenin信号通路与骨关节炎

被引：14

作者：

陶可 ^{[1
]}

熊奡 ^{[2
]}

曾晖 ^{[2
]}

机构：

[1] 汕头大学医学院

[2] 北京大学深圳医院骨关节科

来源：

国际骨科学杂志 | 2010年 / 31卷 / 04期

关键词：

Wnt/β-catenin信号通路; 骨关节炎; 关节发育; 骨软骨细胞; 单核苷酸多态性;

D O I：

暂无

中图分类号：

R684 [关节疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

近年大量研究证实Wnt/β-catenin信号通路通过调节胚胎期软骨发育及出生后软骨发生、成骨细胞和破骨细胞生成、软骨内成骨、骨重塑、骨折修复等过程,调控骨骼系统相关疾病和骨代谢,对骨关节炎(OA)发生发展、骨软骨组织诱导和修复起着至关重要的作用。基因敲除小鼠模型常用于Wnt/β-catenin信号通路与OA关系研究,全基因组扫描已发现一些与OA密切相关的单核苷酸多态性位点。目前在多个水平进行Wnt/β-catenin信号通路靶向治疗OA研究,重点考虑药物安全性。该文就Wnt/β-catenin与OA关系的研究进展作一综述。

引用

收藏

页码：203 / 206

页数：4

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