奥美拉唑联合柴胡疏肝散对胃溃疡患者血清NF-κB及IL-8表达的影响

被引：24

作者：

姜源 ^{[1
]}

胡凤蓉 ^{[2
]}

田莉 ^{[1
]}

许怀利 ^{[1
]}

杨湘敏 ^{[1
]}

申妮 ^{[3
]}

机构：

[1] 西电集团医院消化内科

[2] 西安市第三医院消化内科

[3] 延安大学附属医院消化内科

来源：

现代生物医学进展 | 2018年 / 18卷 / 04期

关键词：

奥美拉唑; 柴胡疏肝散; 胃溃疡; 疗效; 核因子-κB; 白细胞介素-8;

D O I：

10.13241/j.cnki.pmb.2018.04.039

中图分类号：

R573.1 [溃疡病];

学科分类号：

100201 [内科学];

摘要：

目的:研究奥美拉唑联合柴胡疏肝散治疗胃溃疡(Gastric ulcer,GU)的疗效及对血清核因子-κB(NF-κB)、白细胞介素-8(IL-8)表达的影响。方法:研究对象选取我院2015年10月到2016年10月收治的GU患者98例,采用随机数字法将其分为对照组和观察组,每组49例。对照组患者口服奥美拉唑治疗,在此基础上,观察组患者口服柴胡疏肝散治疗。比较两组患者的治疗总有效率、复发率及幽门螺旋杆菌(Helicobacter pylori,Hp)清除率、不良反应发生率及治疗前后的血清IL-8、NF-κB表达的变化。结果:治疗后,观察组的治疗总有效率(93.87%)明显高于对照组(67.64%)(P=0.00),血清IL-8和NF-κB水平均明显低于对照组(P<0.01),复发率明显低于对照组(P<0.05),Hp根除率明显高于对照组(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论:奥美拉唑联合柴胡疏肝散治疗GU的临床疗效显著优于奥美拉唑单药治疗,能促进Hp根除,有效抑制炎症反应,降低疾病复发率,且治疗安全性较高。

引用

收藏

页码：775 / 778

页数：4

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