游离脂肪酸与β细胞功能

Leptin or troglitazoneinducedlipopeniaprotectsisletfrom interleukin 1Bcytotoxicity. Shimabukuro M,Koyama K,Lee Y,etal. The Journal of Clinical Investigation . 1997

The p38/reactivating kinase mitogenactivated protein kinase cascade mediatesthe activation of the transcription factor,insulin upstream factor 1 and insulin genetranscription by high glucose in pancreaticbetacells. Macfarlane WM,Smith SB,James RB,etal. Journal of Biological Chemistry . 1997

Troglitazonelowersislet fat and restores Bcellfunction of Zucker diabeticfatty rats. Shimabukuro M,Zhou YT,Lee Y,et al. Journal of Biological Chemistry . 1998

Role of nitric oxide in obesityinducedbeta celldisease. Shimabukuro M,Ohneda M,Lee Y,etal. The Journal of Clinical Investigation . 1997

Fasting and decreased Bcellsensitivity :importantroleforfatty acidinducedinhibition of PDH activity. Zhou YP,Priestman DA,Randle PJ,etal. American Journal of Physiology . 1996

Inhibitoryeffects of fatty acids on glucoseregulatedBcell function association with increasedislet triglyceride storesand altered effect offatty acid oxidation on glucose metabolism. Zhou YP,Ling ZC,Grill VE. Metabolism . 1996

Differentialexpression ofinsulin genetranscriptional repressor CCAAT/enhancerbinding protein beta andtransactivatorisletduodenum homobox1 in rat pancreatic Bcell during the development of diabetesmellitus. Seufert J,Weir GC,Habener JF,et al. The Journal of Clinical Investigation . 1998

Fatty acids decrease IDX1 expression inrat pancreatic islets and reduce GLUT2 ,glucokinase,insulin ,and somatostatin levels. Gremlich S,Bonny C,Waeber G,et al. Journal of Biological Chemistry . 1997

Fatty acids rapidly induce thecarnitine palmitoyltransferase Igene in thepancreatic Bcellline INS1. Assimacopoulos JF,Thumelin S,RocheE,et al. Journal of Biological Chemistry . 1997

Betacelllipotoxicityin the pathogenesis of noninsulindependent diabetes mellitus of obesrats:impairment in adipocytebetacell relationships. Lee Y,Hirose H,Ohneda M,et al. Proceedings of the National Academy of Sciences of the United States of America . 1994

Leptin or troglitazoneinducedlipopeniaprotectsisletfrom interleukin 1Bcytotoxicity. Shimabukuro M,Koyama K,Lee Y,etal. The Journal of Clinical Investigation . 1997

The p38/reactivating kinase mitogenactivated protein kinase cascade mediatesthe activation of the transcription factor,insulin upstream factor 1 and insulin genetranscription by high glucose in pancreaticbetacells. Macfarlane WM,Smith SB,James RB,etal. Journal of Biological Chemistry . 1997

Troglitazonelowersislet fat and restores Bcellfunction of Zucker diabeticfatty rats. Shimabukuro M,Zhou YT,Lee Y,et al. Journal of Biological Chemistry . 1998

Role of nitric oxide in obesityinducedbeta celldisease. Shimabukuro M,Ohneda M,Lee Y,etal. The Journal of Clinical Investigation . 1997

Fasting and decreased Bcellsensitivity :importantroleforfatty acidinducedinhibition of PDH activity. Zhou YP,Priestman DA,Randle PJ,etal. American Journal of Physiology . 1996

Inhibitoryeffects of fatty acids on glucoseregulatedBcell function association with increasedislet triglyceride storesand altered effect offatty acid oxidation on glucose metabolism. Zhou YP,Ling ZC,Grill VE. Metabolism . 1996

Differentialexpression ofinsulin genetranscriptional repressor CCAAT/enhancerbinding protein beta andtransactivatorisletduodenum homobox1 in rat pancreatic Bcell during the development of diabetesmellitus. Seufert J,Weir GC,Habener JF,et al. The Journal of Clinical Investigation . 1998

Fatty acids decrease IDX1 expression inrat pancreatic islets and reduce GLUT2 ,glucokinase,insulin ,and somatostatin levels. Gremlich S,Bonny C,Waeber G,et al. Journal of Biological Chemistry . 1997

Fatty acids rapidly induce thecarnitine palmitoyltransferase Igene in thepancreatic Bcellline INS1. Assimacopoulos JF,Thumelin S,RocheE,et al. Journal of Biological Chemistry . 1997

Betacelllipotoxicityin the pathogenesis of noninsulindependent diabetes mellitus of obesrats:impairment in adipocytebetacell relationships. Lee Y,Hirose H,Ohneda M,et al. Proceedings of the National Academy of Sciences of the United States of America . 1994