缺氧诱导因子-1α在缺血性脑卒中模型中介导神经干-祖细胞作用机制的研究进展

被引:14
作者
张东圆
李明
王正则
张文冉
许晓丹
张丽莹
田沈
机构
[1] 中国医科大学附属第四医院神经内科
关键词
缺血性脑卒中; 缺氧诱导因子-1α; 神经干-祖细胞; 综述;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)]; R-332 [医用实验动物学];
学科分类号
100204 [神经病学]; 100402 [劳动卫生与环境卫生学];
摘要
缺氧诱导因子-1α(HIF-1α)是一种缺氧应答因子。脑缺血缺氧时,HIF-1α表达上调,调控下游基因表达,对脑缺血后能量代谢障碍的改善以及微循环的建立具有重要意义。神经干-祖细胞的再生能促进脑梗死的功能恢复。HIF-1α可能通过Notch通路、Wnt/β-catenin通路等机制,介导神经干-祖细胞增殖、分化。
引用
收藏
页码:319 / 322
页数:4
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