老年慢性心力衰竭患者血浆脑钠肽前体与左室功能研究

被引：9

作者：

夏思良

周建松

郭振峰

孙红

机构：

[1] 东南大学附属南京江北人民医院心内科

来源：

实用老年医学 | 2009年 / 23卷 / 01期

关键词：

心力衰竭; 脑钠肽前体; 心功能; 超声心动描记术;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨老年慢性心力衰竭(CHF)患者血浆脑钠肽前体(NT-proBNP)水平与左室功能的关系及临床意义。方法102例CHF患者按美国心脏病协会(NYHA)分级方法分为心功能Ⅱ、Ⅲ、Ⅳ级3组,18名健康老年人纳入对照组。电化学发光双抗体免疫夹心法测定4组血浆NT-proBNP,二维超声测定左室舒张末期内径(LVEDD),Simpon双平面法测定左室射血分数(LVEF)。结果心衰各组NT-proBNP水平、LVEDD高于对照组,LVEF低于对照组。血浆NT-proBNP水平、LVEF、LVEDD在4组间两两比较均有统计学差异(P<0.05或P<0.01)。NT-proBNP水平与LVEDD呈正相关(r=0.76,P<0.01),而与LVEF呈负相关(r=-0.68,P<0.01)。结论NT-proBNP可以用来评估老年心衰患者的左室功能,是反映心衰的客观指标。

引用

页码：42 / 44

页数：3

共 12 条

[1]

Two-year stability of NT-proBNP in frozen samples using the Roche Elecsys system. Cauliez B,Guignery S,Marinier S,et al. Annals of Clinical Biochemistry . 2008

[2]

Application of NT-proBNP and BNP measurements in cardiac care:a more discerning marker for the detection and evalution of heart failure. Seino Y,Ogawa A,Yanmashita Tet al. European Journal of Heart Failure . 2004

[3]

Aminoterminal pro type B na-triuretic peptide as a predictive and prognostic marker in patients with chronic heart failure. Rothenburger M,Wichter T,Schmid C. The Journal of Heart and Lung Transplantation . 2004

[4]

Heart[P]. 英国专利:GB0418877D0,2004-09-29

[5]

Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival COPERNICUS) trial. Hartmann,F,Packer,M,Coats,AJ. Circulation . 2004

[6]

Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide ( N-BNP )concentrations. Troughton RW,Frampton CM,Yandle TG,et al. The Lancet . 2000

[7]

Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. Yeo,KT,Wu,AH,Apple,FS,Kroll,MH,Christenson,RH,Lewandrowski,KB,Sedor,FA,Butch,AW. Clinica Chimica Acta . 2003

[8]

Comparison of brain natriuretic peptide(BNP)and amio-terminal proBNP for early diagnosis of heart failure. Emdin M,Passino C,Prontera C,et al. Clinical Chemistry . 2007

[9]

Usefulness of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide to predict cardiovascular outcomes in patients with heart failure and preserved left ventricular ejection fraction. Grewal J,McKelvie RS,Persson H,et al. The American Journal of Cardiology . 2008

[10]

NT-proBNPand the diagnosis of heart failure:a pooled analysis of threeEuropean epidemiological studies. McDonagh TA,Holmer S,Raymond I,et al. European Journal of Heart Failure . 2004

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