脑梗死患者脂蛋白相关磷脂酶A2水平及临床意义

被引：3

作者：

刘香

戴世荣

顾玲莉

机构：

[1] 江苏省南通市第二人民医院检验科

来源：

检验医学与临床 | 2015年 / 12卷 / 23期

关键词：

脂蛋白相关磷脂酶A2; 脑梗死; 诊断效能;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的分析脑梗死患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平的变化,探讨其对脑梗死的临床价值。方法采用免疫增强比浊法检测92例脑梗死患者及68例健康对照者血浆Lp-PLA2、C反应蛋白、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、葡萄糖;采用受试者工作特征曲线评价Lp-PLA2对脑梗死的诊断效能;采用头颅核磁共振检查计算脑梗死灶体积大小,按照美国国立卫生研究所中风量表进行神经功能缺损程度评估;比较脑梗死患者血浆Lp-PLA2水平与脑梗死体积大小,对血浆Lp-PLA2和神经功能缺损程度评分进行相关性分析。结果脑梗死组Lp-PLA2显著高于健康对照组,差异有统计学意义(P<0.05),血浆Lp-PLA2诊断脑梗死的受试者工作特征曲线下面积为0.973,最佳临界值为131.5ng/mL,敏感性为91.3%,特异性为97.1%。Lp-PLA2水平随脑梗死灶体积增大呈上升趋势,差异有统计学意义(P<0.05)。Logistic回归相关分析显示,LpPLA2与神经功能缺损程度呈正相关(r=0.006,P=0.000)。结论脑梗死患者血浆Lp-PLA2水平显著升高,与脑梗死灶体积和神经功能缺损程度密切相关,Lp-PLA2对脑梗死具有良好的诊断效能。

引用

页码：3586 / 3588

页数：3

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