脑缺血后神经血管保护机制和损伤机制研究进展

被引：25

作者：

陆征宇 ^{[1
,2
]}

董强 ^{[1
]}

机构：

[1] 复旦大学附属华山医院神经内科

[2] 中医药大学附属岳阳中西医结合医院神经内科

来源：

中华脑血管病杂志(电子版) | 2013年 / 7卷 / 03期

关键词：

卒中; 脑缺血; 神经保护; 脑损伤; 神经血管单元;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

摘要：

脑梗死是致死性疾病之一,发病率高,严重危害人类健康。尽管各方面的研究不断深入,但是目前仍然缺乏有效的神经保护药物,脑梗死的治疗依然是一个非常棘手的问题。本文从内源性保护机制、谷氨酸受体的双向作用、非谷氨酸依赖的钙失衡损伤机制进行综述,进一步阐释脑缺血后神经血管的保护机制和损伤机制,以求突破神经保护研究的传统框架,寻找神经血管保护

引用

页码：34 / 40

页数：7

共 85 条

[1] Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke..[J].Weihua Guan;Payaningal R Somanath;Anna Kozak;Anna Goc;Azza B El-Remessy;Adviye Ergul;Maribeth H Johnson;Ahmed Alhusban;Sahar Soliman;Susan C Fagan.PLoS ONE.2017, 9
[2] HIF-1 and c-Src Mediate Increased Glucose Uptake Induced by Endothelin-1 and Connexin43 in Astrocytes
Carlos Valle-Casuso, Jose
Gonzalez-Sanchez, Ana
Medina, Jose M.
Tabernero, Arantxa
[J]. PLOS ONE, 2012, 7 (02):
[3] Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia
Qi, Dashi
Liu, Hongzhi
Niu, Jian
Fan, Xing
Wen, Xiangru
Du, Yang
Mou, Jie
Pei, Dongsheng
Liu, Zhian
Zong, Zhimin
Wei, Xianyong
Song, Yuanjian
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 317 (1-2) : 123 - 129
[4] Hypoxia induces angiogenic factors in brain microvascular endothelial cells.[J].J. Luo;J. Martinez;X. Yin;A. Sanchez;D. Tripathy;P. Grammas.Microvascular Research.2011, 2
[5] HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons.[J]..Experimental Neurology.2011, 1
[6] Executive Summary: Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association.[J].Véronique L. Roger;Alan S. Go;Donald M. Lloyd-Jones;Emelia J. Benjamin;Jarett D. Berry;William B. Borden;Dawn M. Bravata;Shifan Dai;Earl S. Ford;Caroline S. Fox;Heather J. Fullerton;Cathleen Gillespie;Susan M. Hailpern;John A. Heit;Virginia J. Howard;Brett M. Kissela;Steven J. Kittner;Daniel T. Lackland;Judith H. Lichtman;Lynda D. Lisabeth;Diane M. Makuc;Gregory M. Marcus;Ariane M
[7] Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke
Jia, Jia
Verma, Saurabh
Nakayama, Shin
Quillinan, Nidia
Grafe, Marjorie R.
Hurn, Patricia D.
Herson, Paco S.
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (11) : 2160 - 2168
[8] Stroke research at a crossroad: asking the brain for directions
Iadecola, Costantino
Anrather, Josef
[J]. NATURE NEUROSCIENCE, 2011, 14 (11) : 1363 - 1368
[9] Emerging mechanisms of disrupted cellular signaling in brain ischemia..[J].Tymianski Michael.Nature neuroscience.2011, 11
[10] Exercise Improves Recovery after Ischemic Brain Injury by Inducing the Expression of Angiopoietin-1 and Tie-2 in Rats
Zheng, Qingping
Zhu, Danian
Bai, Yulong
Wu, Yi
Jia, Jie
Hu, Yongshan
[J]. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 224 (03) : 221 - 228

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