慢性阻塞性肺疾病危险因素

被引:5
作者
周敏
黄绍光
万欢英
机构
[1] 上海第二医科大学附属瑞金医院呼吸科
关键词
慢性阻塞性肺疾病; 危险因素;
D O I
暂无
中图分类号
R563.9 [其他];
学科分类号
摘要
慢性阻塞性肺疾病 (COPD)是环境、遗传及其相互作用共同参与的疾病过程。在环境因素方面除吸烟外还包括儿童时期呼吸道感染、潜伏的腺病毒感染和空气污染等。在遗传因素方面 ,有多种不同功能的候选基因可能参与发病 ;深入了解环境及遗传的各种环节有助于更好的防治该病。
引用
收藏
页码:378 / 380
页数:3
相关论文
共 10 条
  • [1] Genetic Polymorphism in Matrix Metalloproteinase-9 and Pulmonary Emphysema. Matsushita I,Hasegawa K,Nakata K,et al. Biochemical and Biophysical Research Communications . 2001
  • [2] Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Tamarina NA,McMillan WD,Shively VP et al. Journal of Surgery . 1997
  • [3] Regulation of monocyte MMP-9 production by TNF-alpha and a tumor-derived soluble factor(MMPSF). Laber TM,Balkwill FR. British Journal of Cancer . 1998
  • [4] The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Joos L,Hej Q,Shepherdson MB,et al. Human Molecular Genetics . 2002
  • [5] Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Ye S. Matrix Biology . 2000
  • [6] Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease. Matsushita I,Hasegawa K,Nakata K,et al. Biochemical and Biophysical Research Communications . 2002
  • [7] Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10. Fujii T,Hogg JC,Keicho N,et al. American Journal of Physiology Lung Cellular and Molecular Physiology . 2003
  • [8] Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells. Higashimoto Y,Higashimoto Y,Elliott WM,et al. American Journal of Respiratory and Critical Care Medicine . 2002
  • [9] The genetics of chronic obstructive pulmonary disease. Lomas DA,Silverman EK. Respiratory Research . 2001
  • [10] Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease. Hirano K,Sakamoto T,Uchida Y,et al. European Respiratory Journal . 2001