阪崎肠杆菌分类与致病机制

被引:12
作者
吴清平 [1 ]
董晓晖 [1 ,2 ,3 ]
张菊梅 [1 ]
叶应旺 [1 ,2 ,3 ]
徐晓可 [1 ]
杨小鹃 [1 ]
吴葵 [1 ,2 ,3 ]
机构
[1] 广东省微生物研究所,广东省菌种保藏与应用重点实验室,广东省微生物应用新技术公共实验室
[2] 中国科学院南海海洋研究所
[3] 中国科学院研究生院
基金
广东省自然科学基金; 广东省科技计划;
关键词
阪崎肠杆菌; 分类地位; 致病机制;
D O I
10.13343/j.cnki.wsxb.2010.07.018
中图分类号
R155.5 [食品卫生与检验];
学科分类号
100403 ;
摘要
作为一种重要的食源性致病菌,阪崎肠杆菌因能引起新生婴幼儿脑膜炎、坏死性小肠结肠炎而受到了政府和社会的高度重视。2008年,阪崎肠杆菌被提议重新另立为隶属于肠杆菌科的一个包含有5个新种的新属——Cronobacter gen.Nov.。新属的五个种之间毒力作用存在差异,外膜蛋白A在黏附和抗吞噬过程中发挥了重要作用,同时本属菌株的侵入力在宿主细胞间的紧密联系被破坏时显著提高,但是一些肠道益生菌能抑制该菌侵入。目前阪崎肠杆菌的致病研究还比较分散,没有形成系统性,详细的致病机制期待进一步阐明。
引用
收藏
页码:841 / 846
页数:6
相关论文
共 9 条
[1]   The structure of the O-antigen in the endotoxin of the emerging food pathogen Cronobacter (Enterobacter) muytjensii strain 3270 [J].
MacLean, Leann L. ;
Pagotto, Franco ;
Farber, Jeffrey M. ;
Perry, Malcolm B. .
CARBOHYDRATE RESEARCH, 2009, 344 (05) :667-671
[2]   Specific probiotic strains and their combinations counteract adhesion of Enterobacter sakazakii to intestinal mucus [J].
Collado, Maria Carmen ;
Isolauri, Erika ;
Salminen, Seppo .
FEMS MICROBIOLOGY LETTERS, 2008, 285 (01) :58-64
[3]   Outer membrane protein A expression in Enterobacter sakazakii is required to induce microtubule condensation in human brain microvascular endothelial cells for invasion [J].
Singamsetty, Vijay K. ;
Wang, Ying ;
Shimada, Hiroyuki ;
Prasadarao, Nemani V. .
MICROBIAL PATHOGENESIS, 2008, 45 (03) :181-191
[4]   Development of an immobilization and detection method of Enterobacter sakazakii from powdered infant formula [J].
Zhou, Yanhong ;
Wu, Qingping ;
Xu, Xiaoke ;
Yang, Xiaojuan ;
Ye, Yingwang ;
Zhang, Jumei .
FOOD MICROBIOLOGY, 2008, 25 (05) :648-652
[5]  
Analysis of major band of Enterobacter sakazakii by ERIC-PCR and development of a species-specific PCR for detection of Ent. sakazakii in dry food samples[J] . Yingwang Ye,Qingping Wu,Yanhong Zhou,Xiaohui Dong,Jumei Zhang.Journal of Microbiological Methods . 2008 (3)
[6]   Postsurgical osteomyelitis caused by Enterobacter sakazakii in a healthy young man [J].
Corti, G. ;
Panunzi, I. ;
Losco, M. ;
Buzzi, R. .
JOURNAL OF CHEMOTHERAPY, 2007, 19 (01) :94-96
[7]   Isolation of Enterobacter sakazakii and other Enterobacteriaceae from powdered infant formula milk and related products [J].
Iversen, C ;
Forsythe, S .
FOOD MICROBIOLOGY, 2004, 21 (06) :771-777
[8]   Development of a fast DNA-DNA hybridization method based on melting profiles in microplates [J].
Mehlen, A ;
Goeldner, M ;
Ried, S ;
Stindl, S ;
Ludwig, W ;
Schleifer, KH .
SYSTEMATIC AND APPLIED MICROBIOLOGY, 2004, 27 (06) :689-695
[9]  
Identification of Escherichia coli outer membrane protein A receptor on human brain microvascular endothelial cells. Prasadarao, N.V. Infection and Immunity . 2002