脑源性神经营养因子与抑郁症及其执行功能的关联研究

被引：3

作者：

吉峰 ^{[1
]}

戴媛媛 ^{[2
]}

冯玉 ^{[2
]}

杨志寅 ^{[1
]}

机构：

[1] 济宁医学院山东省高校行为与健康人文社科基地

[2] 新乡医学院研究生院

来源：

济宁医学院学报 | 2013年 / 36卷 / 02期

关键词：

抑郁症; 执行功能; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)与抑郁症及其执行功能的关系。方法随机抽取68例抑郁症患者及71例正常人为研究对象,采用ELASA法检测血清BDNF水平、PCR-RFLP技术检测BDNF rs6265多态位点基因多态性,应用威斯康星卡片分类测验(Wisconsin Card Sor-ting Test,WCST)评估执行功能。结果抑郁症组与WCST有关的执行功能明显差于对照组(t=2.02～4.82,P均<0.05);抑郁症组血清BDNF水平低于对照组(t=3.62,P<0.001),其蛋氨酸携带率(89.7%)高于对照组(79.4%)(P<0.05);抑郁症血清BDNF水平与分类数明显相关(r=0.27,P<0.05),携带蛋氨酸组非持续错误数低于非携带蛋氨酸组(z=0.20,P<0.05)。结论血清BDNF水平及其rs6265多态位点基因多态性与抑郁症的执行功能有关。

引用

页码：80 / 83

页数：4

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