微卫星不稳定性与NSCLC临床病理关系研究

被引：5

作者：

徐燕杰

陈乐真

韩永

吕亚丽

钟梅

机构：

[1] 解放军三零九医院病理科

[2] 解放军总医院病理科

来源：

中国肺癌杂志 | 2000年 / 01期

关键词：

非小细胞肺癌; 病理学; 染色体畸变; 预后;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100214 ;

摘要：

目的　明确非小细胞肺癌 (NSCLC)中相关位点微卫星不稳定性 (MSI)的发生率及其与临床病理指标和预后的相关性。方法　应用PCR -变性聚丙烯酰胺 (PAG)技术检测 94例NSCLC肿瘤组织及相应正常肺组织D3S10 67,D3S65 9,D3S966及AR四个位点的MSI ,并与患者临床病理指标及预后进行对比分析。结果　在所有病例中 64 .89% ( 61/94)呈现至少一个位点的MSI阳性。MSI阳性组与MSI阴性组相比较 ,其淋巴结转移率明显增高 ,差异有显著性意义 ( χ2 =9.945 ,P =0 .0 0 2 )。MSI阳性患者的生存时间显著地低于MSI阴性患者 (P =0 .0 0 0 1)。Cox回归模型分析显示 ,MSI对NSCLC患者是一个重要的预后判断因素 ( χ2 =15 .412 6,P =0 .0 0 0 1) ,淋巴结转移在评估预后中也有一定意义 ( χ2 =6.610 8,P =0 .0 10 1)。结论　MSI与NSCLC患者的淋巴结转移有关 ,并且是其生存率和预后判断的一个重要因素

引用

页码：27 / 30

页数：4

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