大黄总蒽醌对小鼠扭体模型的镇痛作用

被引：27

作者：

陈一村

秦永洁

蔡聪艺

白雪婷

石刚刚

机构：

[1] 汕头大学医学院药理学教研室

来源：

现代生物医学进展 | 2010年 / 10卷 / 03期

关键词：

镇痛; 扭体模型; 小鼠; 大黄总蒽醌;

D O I：

10.13241/j.cnki.pmb.2010.03.027

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的:观察大黄总蒽醌对小鼠扭体模型的镇痛作用。方法:60只小鼠随机分为对照组、大黄总蒽醌组、地塞米松组(n=20),给予各组小鼠灌胃相应药物,1次/d,给药5天。于第5天给药后30min用醋酸扭体法测定各组扭体次数。结果:大黄总蒽醌具有较强的镇痛活性,而且呈现出剂量依赖性关系,最大的剂量600mg/kg,可达到55.56%的镇痛效果,大黄总蒽醌组和地塞米松组小鼠的扭体次数少于对照组(P<0.05,P<0.01)。结论:大黄总蒽醌对冰醋酸所致小鼠扭体模型有一定的镇痛作用。

引用

页码：558 / 559

页数：2

共 7 条

[1]

Laetispicine, an amide alkaloid from Piper laetispicum, presents antidepressant and antinociceptive effects in mice [J].

Yao, C. Y. ;

Wang, J. ;

Dong, D. ;

Qian, F. G. ;

Xie, J. ;

Pan, S. L. .

PHYTOMEDICINE, 2009, 16 (09) :823-829

[2]

Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.[J].Yan Ding;Lei Zhao;Hong Mei;Shu-Ling Zhang;Zhi-Hua Huang;Yan-Ying Duan;Pian Ye.European Journal of Pharmacology.2008, 1

[3]

Heat and mechanical hyperalgesia in mice model of cancer pain.[J].Hideaki Asai;Noriyuki Ozaki;Masamichi Shinoda;Kenjiro Nagamine;Iwai Tohnai;Minoru Ueda;Yasuo Sugiura.Pain.2005, 1

[4]

Effect of sumatriptan in different models of pain in rats [J].

Ottani, A ;

Ferraris, E ;

Giuliani, D ;

Mioni, C ;

Bertolini, A ;

Sternieri, E ;

Ferrari, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 497 (02) :181-186

[5]

Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model.[J].James J Lynch;Carrie L Wade;Chengmin M Zhong;Joseph P Mikusa;Prisca Honore.Pain.2004, 1

[6]

Inducible nitric oxide synthase inhibitors of Chinese herbs III.: Rheum palmatum [J].

Wang, CC ;

Huang, YJ ;

Chen, LG ;

Lee, LT ;

Yang, LL .

PLANTA MEDICA, 2002, 68 (10) :869-874

[7]

Effects of fufang yimucao oral liquid on acute ache model mice [J].

Fengjie WangMingsan MiaoYulin ZhangJingjing ShiYalei YangHuili Liu Department of PharmacyHenan College of Traditional Chinese MedicineZhengzhou Henan ProvinceChina .

Neural Regeneration Research, 2007, (06) :372-375

← 1 →