阿片受体激动剂和拮抗剂的联用

被引:8
作者
石靖
许真玉
机构
[1] 国家食品药品监督管理局药品审评中心
关键词
阿片受体激动剂; 阿片受体拮抗剂; 复方; 纳洛酮; 纳曲酮;
D O I
10.13220/j.cnki.jipr.2013.04.017
中图分类号
R971 [神经系统药物];
学科分类号
1007 ;
摘要
阿片受体激动剂是临床常用的镇痛药,通常用于中重度疼痛的治疗,但是此类药物常伴有明显的不良反应,如恶心、呕吐、便秘和呼吸抑制等,同时存在较高的成瘾性和依赖性,大大影响了药物的临床应用。近年来,阿片受体拮抗剂与阿片受体激动剂组成的复方药物陆续上市,临床试验显示此类复方制剂可以减轻不良反应,降低药物滥用的风险,为阿片类镇痛的临床应用提供了新的思路和选择。
引用
收藏
页码:439 / 442
页数:4
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