熊去氧胆酸治疗胆汁淤积性肝病研究进展

被引：18

作者：

付涛 ^{[1
]}

张亚平 ^{[2
]}

机构：

[1] 中国电子科技集团公司第五十四研究所职工医院

[2] 河北医科大学第三医院

来源：

现代中西医结合杂志 | 2017年 / 26卷 / 30期

关键词：

熊去氧胆酸; 胆汁淤积; 肝纤维化; 分子机制;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

<正>胆汁淤积症是指各种原因导致胆汁流的形成和排泌障碍所致的一组共同的临床疾病综合征,能去氧胆酸(UDCA)具有利胆、抗凋亡、抗纤维化作用及促进防御性运转体蛋白表达等功能[1]。目前发现,在肝肠循环中,UDCA为无毒的亲水性胆盐,以替换有毒的疏水性胆盐,从而抑制回肠对疏水性胆盐的重吸收,UDCA通过保护肝细胞膜、改善毛细胆管膜流动性[2]、保护肝细胞、利胆等作用来抑制肝纤维化及肝硬化的

引用

页码：3418 / 3420

页数：3

共 24 条

[1]

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis [J].

Tang, Ning ;

Zhang, Yaping ;

Liu, Zeyu ;

Fu, Tao ;

Liang, Qinghong ;

Ai, Xuemei .

BIOMEDICAL REPORTS, 2016, 5 (01) :107-112

[2]

Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment [J].

Orso, Giuseppe ;

Mandato, Claudia ;

Veropalumbo, Claudio ;

Cecchi, Nicola ;

Garzi, Alfredo ;

Vajro, Pietro .

DIGESTIVE AND LIVER DISEASE, 2016, 48 (03) :215-222

[3]

Ursodeoxycholic acid induces apoptosis of hepatocellular carcinoma cells in vitro [J].

Zhu, Lei ;

Shan, Lu Juan ;

Liu, Yue Jian ;

Chen, Dan ;

Xiao, Xiao Guang ;

Li, Yan .

JOURNAL OF DIGESTIVE DISEASES, 2014, 15 (12) :684-693

[4]

Protective Effects of Norursodeoxycholic Acid Versus Ursodeoxycholic Acid on Thioacetamide-induced Rat Liver Fibrosis [J].

Buko, Vyacheslav U. } ;

Lukivskaya, Oxana Y. ;

Naruta, Elena E. ;

Belonovskaya, Elena B. ;

Tauschel, Horst-Dietmar .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2014, 4 (04) :293-301

[5]

OSU-03012, a non-cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway [J].

Liu, Juan ;

Qin, Cheng-Kun ;

Lv, Wei ;

Zhao, Qi ;

Qin, Cheng-Yong .

ANTI-CANCER DRUGS, 2013, 24 (07) :690-698

[6]

Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis [J].

Bacq, Yannick ;

Sentilhes, Loic ;

Reyes, Humberto B. ;

Glantz, Anna ;

Kondrackiene, Jurate ;

Binder, Tomas ;

Nicastri, Pier Luigi ;

Locatelli, Anna ;

Floreani, Annarosa ;

Hernandez, Ismael ;

Di Martino, Vincent .

GASTROENTEROLOGY, 2012, 143 (06) :1492-1501

[7]

Ursodeoxycholic acid versus placebo; and early term delivery versus expectant management; in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial.[J].Lucy C Chappell;Vinita Gurung;Paul T Seed;Jenny Chambers;Catherine Williamson;James G Thornton.BMJ.2012, jun1

[8]

Pathogenesis of Liver Fibrosis.[J].Virginia Hernandez-Gea;Scott L. Friedman.Annual Review of Pathology: Mechanisms of Disease.2011, 1

[9]

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells.[J].Hongwei He;Albert Mennone;James L. Boyer;Shi‐Ying Cai.Hepatology.2011, 2

[10]

Primary Biliary Cirrhosis [J].

Lindor, Keith D. ;

Gershwin, M. Eric ;

Poupon, Raoul ;

Kaplan, Marshall ;

Bergasa, Nora V. ;

Heathcote, E. Jenny .

HEPATOLOGY, 2009, 50 (01) :291-308

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