胃癌及癌前病变细胞的凋亡与增殖

被引：3

作者：

万榕

高美钦

江淑萍

陈丽英

机构：

[1] 福建医科大学病理学系

[2] 福建省立医院病理科

[3] 福建医科大学病理学系福州

[4] 福州

来源：

福建医科大学学报 | 2001年 / 03期

关键词：

胃肿瘤; 增殖细胞核抗原; 免疫组织化学; 癌前状态;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

目的　了解胃癌及癌前病变中细胞凋亡和增殖状态的变化 ,探讨其在胃癌发生中的作用。　方法　采用脱氧核糖核酸转移酶介导的 d U TP缺口末端标记 (TUNEL )技术和增殖细胞核抗原 (PCNA)免疫组织化学染色法观察 5 8例胃癌、2 7例癌前病变和 15例正常胃粘膜组织中细胞凋亡和增殖状态。　结果　胃癌组织中细胞凋亡指数显著低于胃正常粘膜和胃癌前病变组织 (2 .8% ,6 .3% ,12 % ,P<0 .0 5 ) ;胃癌前病变细胞凋亡指数明显上升 ,显著高于正常胃粘膜 (P<0 .0 5 ) ;在正常胃粘膜、癌前病变及胃癌组织中凋亡 /增殖比率呈递减趋势而细胞增殖指数则呈递增趋势 (P<0 .0 5 ) ;细胞凋亡指数与肿瘤组织类型、分化程度、浸润深度和转移状况无关 (P>0 .0 5 ) ,细胞增殖指数与肿瘤浸润深度和转移状况无关 (P<0 .0 5 )。　结论　细胞凋亡和增殖的失衡可能是胃粘膜组织恶性转化的重要因素之一。

引用

页码：224 / 226+202 +202

页数：4

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