Leptin减轻吗啡对罗猴促性腺激素释放激素脉冲发生器抑制作用的初步报告

被引：10

作者：

陈名道

TamasOrdog

机构：

[1] 上海第二医科大学附属瑞金医院!上海市内分泌研究所

[2] UniversityofNevada!atRenoUSA

来源：

中华内分泌代谢杂志 | 1998年 / 03期

关键词：

瘦素; 促性腺激素释放激素脉冲发生器; 罗猴; 吗啡;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

目的　研究瘦素（ｌｅｐｔｉｎ）对罗猴下丘脑促性腺激素释放激素脉冲发生器（ＧｎＲＨＰＧ）的多单位电脉冲频率骤然增加（ＭＵＡｖｏｌｌｅｙ）的影响。方法　在基础及受吗啡抑制状态时脑室内输注瘦素，记录植入下丘脑内侧基底部电极的电脉冲释放，计算两次ＭＵＡｖｏｌｌｅｙ之间的间期（ＭＶＩ）。结果瘦素可显著减轻吗啡使ＭＶＩ延长的抑制效应，ＭＶＩ在注射吗啡后为对照的２９０％，如脑室内输注瘦素则可使其减少至１６９％（瘦素１．５μｇ／ｋｇ）和１５１％（瘦素７．５μｇ／ｋｇ），Ｐ＜０．０１。结论　瘦素可部分保护ＧｎＲＨＰＧ少受吗啡的抑制。

引用

页码：22 / 26

页数：5

共 12 条

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