小胶质细胞在神经退行性疾病发生发展中的双重作用

被引：7

作者：

苏新辉 ^{[1
]}

豆晓锋 ^{[1
]}

张亚飞 ^{[1
]}

王玮 ^{[2
]}

机构：

[1] 厦门大学附属第一医院核医学科

[2] 福建医科大学

来源：

解剖学研究 | 2013年 / 35卷 / 03期

关键词：

小胶质细胞; 神经退行性疾病; 炎症; 保护功能;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

摘要：

小胶细胞是中枢神经系统的主要免疫细胞,当中枢神经系统受到损伤时,就被激活,一方面产生大量致炎性细胞因子和神经元毒性介质,介导脑内慢性炎症反应、细胞凋亡,导致神经元损伤、死亡;另一方面激活的小胶质细胞也发挥吞噬作用和分泌神经生长因子,具有保护中枢神经系统的功能。本文着重阐述小胶质细胞的双重作用,并对目前一些针对小胶细胞治疗作个介绍。

引用

页码：220 / 224

页数：5

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