尿激酶介入动脉溶栓治疗26例急性脑梗死临床分析

被引：11

作者：

陈光辉

叶飞

秦碧勇

席刚明

机构：

[1] 湖北医药学院附属人民医院(十堰市人民医院)神经内科

来源：

现代生物医学进展 | 2010年 / 10卷 / 24期

关键词：

脑梗死; 脑卒中; 动脉溶栓; 尿激酶;

D O I：

10.13241/j.cnki.pmb.2010.24.047

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的:观察缺血性脑梗死急性期尿激酶介入动脉溶栓治疗的临床疗效。方法:应用尿激酶早期动脉内溶栓治疗急性脑梗死26例。溶栓前及溶栓后2 h、30 d进行神经功能缺损评分,同时观察并发症及疗效。结果:颈内动脉闭塞9例,大脑中动脉主干(M1)段闭塞6例,大脑前动脉闭塞4例,椎基底动脉系统闭塞3例。溶栓治疗后10例获得完全再通,9例部分再通,3例未开通。临床症状完全恢复及明显好转16例,占总病例61.5%。术后NIHSS评分较术前明显提高。并发颅内出血1例。再通后发生再闭塞1例。结论:尿激酶动脉溶栓治疗急性脑梗死安全、有效、可行,但其远期疗效还需进一步观察。

引用

页码：4710 / 4712

页数：3

共 12 条

[1]

Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. The National Institute of Neurological Disorders and Stroke rt PA Stroke Study Group. New England Journal of Medicine, The . 1995

[2]

Intraarterial thrombolytic therapy within 3 hours of the onset of stroke. Bourekas EC, Slivka AP, Shah R, et al. Neurosurgery . 2004

[3]

Intraarterial thrombolysis within the first three hours after acute ischemic stroke in selected patients. Moonis M. Stroke . 2009

[4]

Intra-arterial vs intra-venous. Thrombolysis for anterior cerebral occlusion. Zhang, B,Sun, X,Li, M. et al. Canadian Journal of Neurological Sciences . 2010

[5] Intra-Arterial vs Intra-Venous Thrombolysis for Anterior Cerebral Occlusion [J].

Zhang, Bin ;

Sun, Xiaojiang ;

Li, Minghua ;

Wang, Feng ;

Xu, Dan ;

Duan, Hao ;

Fang, Chun .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2010, 37 (02) :240-244

[6]

Comparison between MRI screeningand CT-plus-MRI screening for thrombolysis within 3 h of ischemicstroke. Yoo SH,Kwon SU,Lee DH,et al. Journal of the Neurological Sciences . 2010

[7] Intraarterial Thrombolysis Within the First Three Hours After Acute Ischemic Stroke in Selected Patients [J].

Moonis, Majaz .

STROKE, 2009, 40 (07) :2611-2612

[8] 经导管动脉溶栓治疗急性脑梗死的临床观察 [J].

卓安民 ;

孙祖杰 .

实用临床医药杂志, 2008, 12 (12) :56-57

[9]

Fibrinolytic Therapy for Acute Embolic Stroke: Intravenous, Intracarotid, and Intra-arterial Local Approaches[J] . Osamu Sasaki,Shigekazu Takeuchi,Tetsuo Koike,Takayuki Koizumi,Ryuichi Tanaka. &nbspNeurosurgery . 1995 (2)

[10]

Combined thrombolysis withabciximab and rtPA in patients with middle cerebral artery occlusion. Gahn G,Barlinn K,Dzialowski I,et al. Acta Neurologica Scandinavica . 2010

← 1 2 →