中国人群非综合征性唇腭裂TGFA基因TaqⅠ多态性研究

被引：17

作者：

苍松

焦晓辉

王丽

于旸

赵昱辉

李钰

机构：

[1] 哈尔滨医科大学第二临床医学院口腔颌面外科

[2] 哈尔滨医科大学遗传学教研室

来源：

哈尔滨医科大学学报 | 2002年 / 05期

关键词：

唇裂; 腭裂; 遗传学; 转化生长因子-α;

D O I：

暂无

中图分类号：

R782.2 [口腔颌面部整形外科学];

学科分类号：

摘要：

目的　探讨转化生长因子 α(TGFA)与中国人群非综合征性唇腭裂 (NS CL P)的关系。方法　应用聚合酶链式反应 (PCR)结合限制性内切酶酶切 (RFLP)方法 ,对 10 3名健康体检者和 12 4名非综合征性唇腭裂患者进行TG FA基因多态性检测。PCR后直接用限制性内切酶酶切检测基因多态性。结果　单侧唇裂伴腭裂和双侧唇裂伴腭裂均与正常对照组有显著性差异。而单侧唇裂和单纯性腭裂与正常对照组无显著性差异。有家族史患者与无家族史患者等位基因频数在统计学上无显著性差异。结论　中国人群非综合征性唇腭裂TGFA基因中存在TaqⅠ多态性位点 ,TGFATaqI位点与中国人群非综合征性唇腭裂相关。

引用

页码：369 / 371

页数：3

共 6 条

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