miR-328、miR-147和miR-22在冠心病患者中的表达变化及临床意义

被引：13

作者：

冯荣 ^{[1
]}

傅广 ^{[1
]}

黄树斌 ^{[1
]}

石顺华 ^{[1
]}

汤华 ^{[1
]}

王爱平 ^{[2
]}

机构：

[1] 长沙市第一医院心血管内一科

[2] 南华大学医学院人体解剖学教研室

来源：

中国动脉硬化杂志 | 2015年 / 08期

关键词：

miR-328; miR-147; miR-22; 冠心病;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的探讨冠心病患者血浆及外周血单个核细胞(PBMC)miR-328、miR-22、miR-147的表达变化及其临床意义。方法筛选100例冠心病患者及相对健康对照组,采用实时荧光定量PCR技术检测各组血浆及PBMC中miR-328、miR-147、miR-22的表达水平。结果冠心病患者血浆中miR-328、miR-22的表达较非冠心病患者明显升高,而miR-147的表达明显降低;在冠心病患者PBMC中,miR-328表达没有明显变化,miR-22表达略微增加,miR-147表达明显下降。在心肌梗死患者中,血浆中miR-328和miR-22表达水平明显增加,而miR-147表达明显下降;心肌梗死患者PBMC中miR-328表达略降低,miR-22表达增加,miR-147表达水平略有下降。结论 miR-328、miR-22及miR-147在冠心病患者中的差异表达,有望作为冠心病疾病中一种新的标记物或基因治疗靶点。

引用

页码：812 / 816

页数：5

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