吴茱萸碱抗肿瘤活性研究进展

被引：15

作者：

张醇

梁华平

机构：

[1] 第三军医大学大坪医院野战外科研究所创伤烧伤与复合伤国家重点实验室

来源：

中国新药杂志 | 2010年 / 19卷 / 17期

关键词：

吴茱萸碱; 细胞周期; 凋亡; 坏死; 侵袭转移;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

吴茱萸碱是传统中药吴茱萸中的主要生物碱之一,除具有抗炎、降低血糖等作用外,还具有抗肿瘤活性。研究发现,吴茱萸碱一方面能抑制肿瘤细胞生长,引起细胞周期阻滞于G2/M期或G0/G1期,并改变细胞周期相关蛋白的表达;另一方面能通过多条信号通路,如依赖于caspase、凋亡诱导因子(AIF)或通过核因子κB(NF-κB)、P38 MAPK/ERK等通路诱导细胞凋亡、坏死,从而提高肿瘤细胞的死亡率。此外,吴茱萸碱还能在体外抑制肿瘤细胞合成血管内皮生长因子(VEGF)以及与血管生成相关的多种酶的活化,从而抑制血管生成,并且在体内体外抑制肿瘤细胞的浸润和转移。

引用

页码：1558 / 1562

页数：5

共 6 条

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