由CPVA-g-PSSS功能接枝微球构建pH依赖型5-ASA结肠定位释药体系

被引：5

作者：

门吉英

高保娇

么兰

张妍妍

机构：

[1] 中北大学化学工程系

来源：

过程工程学报 | 2012年 / 12卷 / 04期

基金：

山西省青年科学基金;

关键词：

对苯乙烯磺酸钠; 交联聚乙烯醇微球; 接枝聚合; 5-氨基水杨酸; pH依赖性; 结肠定位释放;

D O I：

暂无

中图分类号：

R94 [药剂学];

学科分类号：

100702 [药剂学];

摘要：

采用铈盐-羟基氧化还原引发体系,在交联聚乙烯醇(CPVA)微球表面引发接枝聚合对苯乙烯磺酸钠(SSS),制备了接枝聚阴离子的功能接枝微球CPVA-g-PSSS,研究了其对5-氨基水杨酸(5-ASA)的吸附(载药)性能、机理和释放行为.结果表明,在酸性介质中,受强静电相互作用驱动,CPVA-g-PSSS对5-ASA分子表现出很强的吸附能力,吸附容量达39.1mg/g,可实现有效载药.载药微球的释药行为具有强烈的pH值依赖性,在pH=1的介质中基本不释药,而在pH=7.4的介质中发生突释,释放率可达86%,表现出良好的结肠定位释放行为.

引用

页码：660 / 664

页数：5

共 15 条

[1]

接枝微球CPVA-g-PSSS的制备及其对5-氟尿嘧啶载药及体外结肠定位释药特性研究 [J].

门吉英 ;

高保娇 ;

陈志萍 .

高分子学报, 2012, (09) :943-951

[2]

水溶性高分子链中磺酸盐基团含量的电导滴定测定法 [J].

高保娇 ;

吴念 ;

李延斌 ;

徐立 .

高分子学报, 2004, (04) :605-609

[3]

Design; characterization and in vitro evaluation of 5-aminosalicylic acid loaded N -succinyl-chitosan microparticles for colon specific delivery.[J].C. Mura;A. Nácher;V. Merino;M. Merino-Sanjuán;M. Manconi;G. Loy;A.M. Fadda;O. Díez-Sales.Colloids and Surfaces B: Biointerfaces.2012,

[4]

In vitro study of N-succinyl chitosan for targeted delivery of 5-aminosalicylic acid to colon [J].

Mura, Carla ;

Manconi, Maria ;

Valenti, Donatella ;

Manca, Maria Letizia ;

Diez-Sales, Octavio ;

Loy, Giuseppe ;

Fadda, Anna Maria .

CARBOHYDRATE POLYMERS, 2011, 85 (03) :578-583

[5]

N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats [J].

Mura, C. ;

Nacher, A. ;

Merino, V. ;

Merino-Sanjuan, M. ;

Carda, C. ;

Ruiz, A. ;

Manconi, M. ;

Loy, G. ;

Fadda, A. M. ;

Diez-Sales, O. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 416 (01) :145-154

[6]

Novel microbially triggered colon specific delivery system of 5-Fluorouracil: Statistical optimization; in vitro ; in vivo ; cytotoxic and stability assessment.[J].Rakesh Kumar Dev;Vikas Bali;Kamla Pathak.International Journal of Pharmaceutics.2011, 1

[7]

Chitosan–silicate biocomposites to be used in modified drug release of 5-aminosalicylic acid (5-ASA).[J].C. Aguzzi;P. Capra;C. Bonferoni;P. Cerezo;I. Salcedo;R. Sánchez;C. Caramella;C. Viseras.Applied Clay Science.2010, 1

[8]

Novel pectin–4-aminothiophenole conjugate microparticles for colon-specific drug delivery.[J].Glen Perera;Jan Barthelmes;Andreas Bernkop-Schnürch.Journal of Controlled Release.2010, 3

[9]

Synthesis and anaerobic biodegradation of indomethacin-conjugated cellulose ethers used for colon-specific drug delivery [J].

Cai, Xiang ;

Yang, Liqun ;

Zhang, Li-Ming ;

Wu, Qing .

BIORESOURCE TECHNOLOGY, 2009, 100 (18) :4164-4170

[10]

pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model [J].

Makhof, Abdallah ;

Tozuka, Yuichi ;

Takeuchi, Hirofumi .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2009, 72 (01) :1-8

← 1 2 →