低盐饮食对高果糖引起血管重构的保护作用

被引：4

作者：

张玲玉 ^{[1
]}

李思琦 ^{[1
]}

吴东 ^{[2
]}

陈浩佳 ^{[2
]}

王丽京 ^{[1
]}

郑凌云 ^{[1
]}

机构：

[1] 广东药科大学基础学院

[2] 广东药科大学公共卫生学院

来源：

重庆医学 | 2018年 / 47卷 / 07期

关键词：

膳食,限钠; 螺内酯; 果糖; 血管重构;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

目的探究低盐饮食对高果糖引起血管重构的保护作用。方法选取Wistar雄性大鼠42只,体质量180～200g,共饲养8周,随机分6组:（1）对照组,给予正常大鼠饲料及蒸馏水;（2）高果糖组（HF组）,给予正常饲料（0.5%NaCl,w/w）及果糖水（10%,w/v）;（3）高盐组（HNa组）,给予高盐饲料（7%NaCl,w/w）和蒸馏水;（4）高果糖联合高盐组（HFNa组）,给予高盐饲料同时给予10%果糖水;（5）高果糖联合低盐组（HFLNa组）,给予低盐饲料（0.07%NaCl,w/w）同时给予10%果糖水;（6）高果糖联合螺内酯组（HFE组）,给予10%果糖水4周后,加入HFE(50mg·kg-1·d-1管饲法),再持续4周。检测各组大鼠动脉血压、血管壁组织学评价,以及α-SMA、纤连蛋白等在血管壁的表达变化。结果（1）与对照组血压（111.03±9.17）mm Hg相比,HF组（133.94±5.86）mm Hg与HNa组（128.09±7.56）mm Hg血压均显著升高（P<0.05）;（2）HF主要引起血管壁中层平滑肌增生,HF组α-SMA的表达结果（0.006 3±0.000 2）与对照组（0.004 6±0.000 3）相比明显增加（P<0.05）,且弹力纤维增多;而HNa则主要刺激弹力纤维增粗,纤连蛋白在HNa组（0.002 6±0.000 2）和HF组（0.004 7±0.000 2）的表达与对照组（0.001 3±0.000 1）相比显著增多（P<0.001）;（3）HFLNa组（106.04±9.59）mm Hg和HFE组（103.99±7.12）mm Hg血压与HF组血压相比明显降低（P<0.05）;且HFLNa组（0.006 8±0.000 2）和HFE组（0.004 2±0.000 4）的血管重构得到改善,α-SMA表达与HF组（0.006 3±0.000 2）相比显著减少（P<0.05）。结论低盐饮食可有效改善HF引起的血管重构。

引用

页码：875 / 878+882 +882

页数：5

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