Exosomes: roles and therapeutic potential in osteoarthritis

被引：45

作者：

Zhenhong Ni ^{[1
]}

Siru Zhou ^{[2
,3
,4
]}

Song Li ^{[1
,5
]}

Liang Kuang ^{[1
]}

Hangang Chen ^{[1
]}

Xiaoqing Luo ^{[1
]}

Junjie Ouyang ^{[1
]}

Mei He ^{[1
]}

Xiaolan Du ^{[1
]}

Lin Chen ^{[1
]}

机构：

[1] Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of

[2] State Key Laboratory of Trauma, Burns and Combined Injury

[3] Medical Cformation of H-type vessel in subchondral enter of Trauma and War Injury

[4] Daping Hospital, Army Medical University of PLA

[5] Eleven Squadron Three Brigade, School of Basic Medical Science, Army Medical University

来源：

Bone Research | 2020年 / 02期

关键词：

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

引用

页码：139 / 156

页数：18

共 95 条

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