骨关节炎治疗靶点p38MAPK信号通路研究进展

被引：42

作者：

于波 ^{[1
,2
]}

朱振安 ^{[1
]}

机构：

[1] 上海交通大学医学院附属第九人民医院骨科、上海市骨科内植物重点实验室

[2] 山东中医药大学附属医院骨科

来源：

国际骨科学杂志 | 2011年 / 32卷 / 06期

关键词：

关节软骨; p38丝裂原活化蛋白激酶; 骨关节炎;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

p38丝裂原活化蛋白激酶(MAPK)在正常软骨细胞生理及骨关节炎病理进程中起重要的调控作用。p38MAPK可调控软骨细胞增殖、生存,细胞外基质代谢平衡,在基质金属蛋白酶、促炎症因子等导致的骨关节炎软骨退变病理进程中具有关键作用。深入研究p38MAPK信号通路与骨关节炎的关系,有助于为骨关节炎防治研究开辟新途径。该文就p38MAPK信号通路作为骨关节炎治疗靶点的近年研究进展作一综述。

引用

页码：343 / 345

页数：3

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