结缔组织生长因子与器官纤维化的关系

被引:3
作者
叶旭军
徐启勇
叶燕青
机构
[1] 武汉大学中南医院呼吸科
关键词
结缔组织生长因子; 转化生长因子; 纤维化;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
结缔组织生长因子 (CTGF)是一种新的可刺激成纤维细胞增殖和分泌胶原的生长因子 ,与肺、肝、肾、心脏、皮肤等器官的纤维化有重要联系。CTGF基因属即刻早期基因 ,启动子含转化生长因子 β应答元件 ,可被TGF β选择性诱导激活 ,并作为其下游介质促进胶原合成。以CTGF为特异性靶标将给器官纤维化治疗开创新纪元。
引用
收藏
页码:139 / 142
页数:4
相关论文
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