一氧化氮合酶选择性抑制剂设计的生化基础

被引:6
作者
徐洪
机构
[1] 中国药科大学新药研究中心!南京
关键词
一氧化氮; 一氧化氮合酶; 同工酶; 选择性抑制剂;
D O I
10.13220/j.cnki.jipr.1998.04.004
中图分类号
R914.2 [药物设计];
学科分类号
摘要
在体内 ,NO由 3种一氧化氮合酶 (NOS)同工酶催化产生 :内皮型 NOS(ec NOS)、诱生型 NOS(i NOS)和脑型 NOS(n NOS)。选择性抑制 i NOS有益于不同形式的休克和炎症的治疗 ,而对 n NOS的抑制可保护神经不受损伤。本文介绍了 NOS同工酶选择性抑制剂设计的生化基础和现有的选择性抑制剂研究概况
引用
收藏
页码:203 / 207
页数:5
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