强直性脊柱炎骨量丢失的中西医结合诊治进展

被引:22
作者
马丽瑶 [1 ]
李涯松 [2 ]
机构
[1] 浙江中医药大学
[2] 浙江省人民医院风湿免疫科
关键词
中医中药; 强直性脊柱炎; 骨丢失; 中西医结合;
D O I
暂无
中图分类号
R593.23 [强直性脊柱炎];
学科分类号
100201 [内科学];
摘要
强直性脊柱炎是一种慢性进行性骨关节病,主要影响中轴骨骼并导致显着的疼痛和残疾。多见于青少年,主要侵犯骶髂关节、髋关节和脊柱,并且可伴有关节外表现。早期表现为肌腱、韧带附着点的炎症,进而出现关节骨质破坏,软骨内、韧带纤维化及异位骨化,造成脊柱关节强直改变,最终导致残废。在我国强直性脊柱炎的发病率约为0.3%,是临床最常见的风湿病之一,发病高峰年龄为15~30岁,男性的患病率比女性高2~3倍,且男性平均发病年龄要早于女性平均发病年龄。骨质疏松作为强直性脊柱炎最常见的一种并发症,以全身性骨病,以骨各种成分等比例减少而导致骨脆性增加、易发生骨折为特征,其发生率为50%92%,并且有35%的强直性脊柱炎患者可发生因骨质疏松而导致椎体压缩性骨折。目前,强直性脊柱炎的治疗主要以西医为主,存在明显的局限性,中医中药可以充分弥补其不足,中西医结合多途径多靶点阻断骨量丢失,可望能为强直性脊柱炎的治疗拓展新思路,提供新方法。
引用
收藏
页码:136 / 140
页数:5
相关论文
共 22 条
[1]
Effects of physical therapy for the management of patients with ankylosing spondylitis in the biological era [J].
Giannotti, Erika ;
Trainito, Sabina ;
Arioli, Giovanni ;
Rucco, Vincenzo ;
Masiero, Stefano .
CLINICAL RHEUMATOLOGY, 2014, 33 (09) :1217-1230
[2]
Effects of Pilates, McKenzie and Heckscher training on disease activity, spinal motility and pulmonary function in patients with ankylosing spondylitis: a randomized controlled trial [J].
Rosu, Mihaela Oana ;
Topa, Ionut ;
Chirieac, Rodica ;
Ancuta, Codrina .
RHEUMATOLOGY INTERNATIONAL, 2014, 34 (03) :367-372
[3]
Should non-steroidal anti-inflammatory drugs be used continuously in ankylosing spondylitis? [J].
Guellec, Dewi ;
Nocturne, Gaetane ;
Tatar, Zuzana ;
Thao Pham ;
Sellam, Jeremie ;
Cantagrel, Alain ;
Saraux, Alain .
JOINT BONE SPINE, 2014, 81 (04) :308-312
[4]
Thalidomide reduces recurrence of ankylosing spondylitis in patients following discontinuation of etanercept [J].
Deng, Xiaohu ;
Zhang, Jianglin ;
Zhang, Jie ;
Huang, Feng .
RHEUMATOLOGY INTERNATIONAL, 2013, 33 (06) :1409-1413
[5]
High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review [J].
van der Weijden, M. A. C. ;
Claushuis, T. A. M. ;
Nazari, T. ;
Lems, W. F. ;
Dijkmans, B. A. C. ;
van der Horst-Bruinsma, I. E. .
CLINICAL RHEUMATOLOGY, 2012, 31 (11) :1529-1535
[6]
The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis [J].
Baskan, Bedriye Mermerci ;
Dogan, Yasemin Pekin ;
Sivas, Filiz ;
Bodur, Hatice ;
Oezoran, Kuersat .
RHEUMATOLOGY INTERNATIONAL, 2010, 30 (03) :375-381
[7]
Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formation [J].
Eguchi, Yoshitaka ;
Wakitani, Shigeyuki ;
Imai, Yuuki ;
Naka, Yoshifumi ;
Hashimoto, Yuusuke ;
Nakamura, Hiroaki ;
Takaoka, Kunio .
JOURNAL OF BONE AND MINERAL METABOLISM, 2010, 28 (02) :157-164
[8]
Association of 1.25 vitamin D3 deficiency, disease activity and low bone mass in ankylosing spondylitis [J].
Lange, U ;
Teichmann, J ;
Strunk, J ;
Müller-Ladner, U ;
Schmidt, KL .
OSTEOPOROSIS INTERNATIONAL, 2005, 16 (12) :1999-2004
[9]
Relationship between disease activity and serum levels of vitamin D metabolites and parathyroid hormone in ankylosing spondylitis [J].
Lange, U ;
Jung, O ;
Teichmann, J ;
Neeck, G .
OSTEOPOROSIS INTERNATIONAL, 2001, 12 (12) :1031-1035
[10]
Bone mass in axial spondyloarthritis: A literature review [J].
Kilic, Erkan ;
Ozgocmen, Salih .
WORLD JOURNAL OF ORTHOPEDICS, 2015, 6 (02) :298-310