细胞色素氧化酶CYP3A4基因多态性研究进展

被引：10

作者：

李艳梅 ^{[1
]}

王刚 ^{[1
]}

黄志 ^{[1
]}

吴惧 ^{[2
]}

机构：

[1] 重庆医科大学附属儿童医院

[2] 四川省成都市儿童医院

来源：

儿科药学杂志 | 2011年 / 17卷 / 06期

关键词：

CYP3A4; 野生型; 咪达唑仑; 编码区; 尼非地平; 基因多态性; 遗传多态性;

D O I：

10.13407/j.cnki.jpp.1672-108x.2011.06.026

中图分类号：

R968 [遗传药理学];

学科分类号：

100602 ; 100706 ;

摘要：

<正>CYP3A4是人类肝脏及肠道中一种主要的细胞色素P450酶,约占成人肝脏P450酶总量的25%,体内许多药物、内源性化合物和环境污染物都由它代谢,大约有38个类别共150多种药物是它的底物,涉及抗癫痫药、抗精神病药、大环内酯类抗生

引用

页码：49 / 52

页数：4

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