同型半胱氨酸与冠状动脉粥样硬化性心脏病的相关性研究进展

被引：34

作者：

曾双龙 ^{[1
,2
]}

徐俊波 ^{[2
]}

胡咏梅 ^{[2
]}

机构：

[1] 遵义医学院

[2] 成都市第二人民医院心内科

来源：

心血管病学进展 | 2012年 / 33卷 / 05期

关键词：

同型半胱氨酸; 冠状动脉粥样硬化性心脏病; 危险因素; 维生素B; 叶酸;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

虽然经历了40余年的漫长研究,但高同型半胱氨酸血症是冠状动脉粥样硬化性心脏病的预测因子还是危险因素目前仍无定论。系列临床观察性研究及其荟萃分析一致显示轻、中度高同型半胱氨酸血症对冠状动脉粥样硬化性心脏病的发生和预后有独立预测价值,而近期以冠状动脉粥样硬化性心脏病患者为主要研究对象的大型随机对照试验却证实补充维生素B(包括叶酸)尽管能有效降低血浆同型半胱氨酸水平,但不能减少心血管事件,尤其是冠状动脉粥样硬化性心脏病事件,这对高同型半胱氨酸血症在冠状动脉粥样硬化性心脏病发病中的作用提出了质疑。为更好地指导临床抉择,现对近年来两者的相关性研究进展做一综述。

引用

页码：650 / 653

页数：4

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