吗啡联合小剂量阿片受体拮抗剂应用研究进展

被引：3

作者：

高明龙

刘永哲

张宏

机构：

[1] 解放军总医院麻醉手术中心

来源：

国际药学研究杂志 | 2007年 / 04期

关键词：

吗啡; 副作用; 耐受和依赖; 阿片受体拮抗剂; 镇痛;

D O I：

10.13220/j.cnki.jipr.2007.04.066

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

吗啡是临床常用的强效阿片类镇痛药,临床应用中出现恶心、呕吐、镇静、瘙痒、便秘、尿潴留、呼吸抑制等副作用,长期应用又出现耐受和依赖。大剂量阿片受体拮抗剂能拮抗吗啡所产生的全部效应,而小剂量的阿片受体拮抗剂不仅能减少或减轻吗啡所致的副作用,还能增强吗啡的镇痛效能。本文就小剂量阿片受体拮抗剂与吗啡的联合应用、小剂量阿片受体拮抗剂增强吗啡镇痛效能、减弱吗啡耐受和依赖的作用机制,以及拮抗副作用等方面的研究进展进行综述。

引用

页码：250 / 253

页数：4

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