非酒精性脂肪性肝病发病机制及治疗进展

被引：26

作者：

武绍梅

马岚青

机构：

[1] 昆明医科大学第一附属医院消化内科

来源：

医学综述 | 2014年 / 20卷 / 24期

关键词：

胰岛素抵抗; 非酒精性脂肪性肝炎; 二甲双胍; 噻唑烷二酮;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

非酒精性脂肪性肝病(NAFLD)是代谢综合征在肝脏的组成部分,是全球范围内广泛流行的慢性肝病。胰岛素抵抗(IR)可引起肝脏糖脂代谢紊乱,导致脂肪变。脂肪因子和炎性因子相互作用可导致IR,引起脂肪肝炎性改变,使NAFLD患者进展为非酒精性脂肪性肝炎(NASH)、肝纤维化甚至肝细胞癌。鉴于此,胰岛素增敏剂二甲双胍及噻唑烷二酮类药物能有效地治疗NAFLD。该文就NAFLD的发病机制与胰岛素增敏剂抗病机制及疗效予以综述。

引用

页码：4455 / 4458

页数：4

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