西尼地平的抗高血压作用及交感神经抑制活性

被引:4
作者
汪光宝
陈刚
关飙
陈飞虎
机构
[1] 安徽医科大学药学系
[2] 安徽医科大学第一附属医院心内科
[3] 安徽丰原药业股份有限公司
[4] 安徽医科大学药学系 合肥
[5] 合肥
关键词
西尼地平; N-型钙通道阻滞剂; 交感神经抑制活性;
D O I
暂无
中图分类号
R965 [实验药理学];
学科分类号
100602 ; 100706 ;
摘要
目的 介绍西尼地平的临床前药理研究及临床应用。方法 检索Medline ,查找原文。结果 西尼地平不仅能阻滞血管平滑肌上的L 型Ca2 + 通道 ,还能阻滞交感神经元上的N 型Ca2 + 通道。西尼地平无降压所导致的反射性交感神经兴奋 ,对原发性高血压病人能有效降压 ,且不引起心率加快。结论 西尼地平可能会成为新一代抗高血压的典型药物
引用
收藏
页码:313 / 315
页数:3
相关论文
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