Th17细胞研究进展

被引：5

作者：

王敏

王宁玲

王会平

机构：

[1] 安徽医科大学第二附属医院儿科

来源：

国际儿科学杂志 | 2011年 / 02期

关键词：

CD4+T细胞; Th17; IL-17;

D O I：

暂无

中图分类号：

R392.1 [免疫生物学];

学科分类号：

摘要：

Th17细胞是一类新型CD4+T细胞,它与Th1、Th2、调节性T细胞一起构成了CD4+T细胞的4个主要亚群。Th17细胞的分化过程需要IL-6和转化生长因子-β、转录因子孤独核受体γt及信号传导和转录激活子3等参与,这一分化过程在细胞和分子水平都受到精细的调节。Th17细胞分泌IL-17、IL-22、IL-6等多种细胞因子,在自身免疫性疾病、感染性疾病和移植排斥中发挥着重要作用。因此,Th17细胞及相关细胞因子可能为此类疾病的治疗提供新的靶点和途径。

引用

页码：181 / 185

共 6 条

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